Klingelhoefer Lisa, Reichmann H
Department of Neurology, Technical University Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
J Neural Transm (Vienna). 2017 Jun;124(6):709-713. doi: 10.1007/s00702-017-1692-0. Epub 2017 Feb 2.
This article summarises the noteworthy contribution of Professor Jellinger to the understanding of Parkinson's disease (PD) as a disease affecting multiple body- and neurotransmitter-systems. Phosphorylated alpha-synuclein and the formation of Lewy pathology as neuropathological hallmarks of PD seem to spread from the enteric nervous system and the olfactory bulb in a rostrocranial direction to the CNS. Subsequently, a progressive degeneration of the dopaminergic-nigrostriatal system and widespread extranigral pathology affecting different anatomical structures and neurotransmitters are induced causing the various non-motor and motor symptoms of PD.
本文总结了杰林格教授在将帕金森病（PD）理解为一种影响多个身体和神经递质系统的疾病方面所做出的显著贡献。磷酸化α-突触核蛋白以及路易病理的形成作为PD的神经病理学标志，似乎从肠神经系统和嗅球沿头侧方向扩散至中枢神经系统。随后，多巴胺能黑质纹状体系统逐渐退化，并引发影响不同解剖结构和神经递质的广泛黑质外病理改变，从而导致PD的各种非运动和运动症状。
