Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati 781039, India.
Department of Chemistry, Aligarh Muslim University , Aligarh 202002, India.
J Org Chem. 2017 Feb 17;82(4):2089-2096. doi: 10.1021/acs.joc.6b02912. Epub 2017 Feb 9.
The in situ generated o-alkynylthioureas obtain by reacting 2-(phenylethynyl)anilines and aryl isothiocynates undergo efficient cascade cyclization in the presence of AgCO to form indoloquinolines under microwave heating. The present tandem process allows the generation of a variety of indolo[2,3-b]quinolines derivatives in good to moderate yields with a wide functional group tolerance.
在微波加热条件下，通过 2-（苯乙炔基）苯胺和芳基异硫氰酸酯原位生成的 o-炔基硫脲在 AgCO 的存在下经历有效的级联环化反应，形成吲哚喹啉。该串联过程可以在宽官能团容忍度的情况下，以良好至中等的收率生成各种吲哚[2,3-b]喹啉衍生物。
