Kozhevnikova K A, Petrova-Maslakova L G, Parfenova N S, Belova E V, Triufanov V F, Noskin V A, Vavrin R Z
Vopr Med Khim. 1989 Jul-Aug;35(4):43-8.
Both subfraction "2" of high density lipoproteins (HDL2) from patients with hypo-alpha-lipoproteinemia and subfraction HDL3 from persons with normal content of cholesterol were shown to accept the erythrocyte membranes cholesterol in vitro. Under these conditions HDL3 subfraction was transformed into HDL2-like particles, where content of unesterified cholesterol and its esters was increased simultaneously with enlargement of the particles size. The HDL subfraction, isolated from persons with high content of cholesterol, did not accept cholesterol under the experimental conditions. Apoprotein E, containing in the HDL subfractions, was not responsible for the particles cholesterol-accepting properties. Apoprotein E itself was capable of cholesterol elimination from erythrocytes as well as of cholesterol esters from HDL3 and HDL2-like particles with formation of a specific complex.
低α脂蛋白血症患者的高密度脂蛋白（HDL2）的亚组分“2”和胆固醇含量正常者的HDL3亚组分在体外均显示能接受红细胞膜胆固醇。在这些条件下，HDL3亚组分转化为类似HDL2的颗粒，其中未酯化胆固醇及其酯的含量随着颗粒大小的增大而同时增加。从胆固醇含量高的人分离出的HDL亚组分在实验条件下不接受胆固醇。HDL亚组分中含有的载脂蛋白E与颗粒的胆固醇接受特性无关。载脂蛋白E本身能够从红细胞中清除胆固醇，也能从HDL3和类似HDL2的颗粒中清除胆固醇酯，形成一种特定的复合物。
