MTA-ELTE "Lendület" Catalysis and Organic Synthesis Research Group, Eötvös Loránd University , Institute of Chemistry Pázmány Péter stny. 1/A, Budapest, 1117, Hungary.
Eötvös Loránd University , Institute of Chemistry, Pázmány Péter stny. 1/A, Budapest, 1117, Hungary.
Org Lett. 2017 Feb 17;19(4):954-957. doi: 10.1021/acs.orglett.7b00259. Epub 2017 Feb 3.
A novel catalytic method for the direct C-H alkynylation of azulenes is developed. The gold catalyzed functionalization of this special carbacycle is achieved with hypervalent iodonium reagent TIPS-EBX under mild reaction conditions. With the aid of the developed procedure, several TIPS alkynylated azulene derivatives were synthesized bearing important functional groups for further functionalization.
发展了一种新型的靛红催化 C-H 炔基化方法。在温和的反应条件下，使用高价碘翁试剂 TIPS-EBX 实现了这种特殊碳环的金催化官能化。借助所开发的方法，合成了几种带有重要官能团的 TIPS 炔基化靛红衍生物，可进一步进行官能化。
