细胞周期磷酸化的时间顺序。

The Temporal Ordering of Cell-Cycle Phosphorylation.

机构信息

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305-5307, USA.

出版信息

Mol Cell. 2017 Feb 2;65(3):371-373. doi: 10.1016/j.molcel.2017.01.025.

DOI:10.1016/j.molcel.2017.01.025

PMID:28157499

Abstract

Cell-cycle phosphorylation is temporally ordered, at least in part, through the sequential expression of different cyclins. Recent studies by Swaffer et al. (2016) and Godfrey et al. (2017) show that intrinsic properties of the substrate proteins contribute as well: good kinase substrates tend to be phosphorylated early, and good phosphatase substrates tend to be phosphorylated late.

摘要

细胞周期的磷酸化在时间上是有序的，至少部分是通过不同细胞周期蛋白的顺序表达来实现的。最近 Swaffer 等人（2016 年）和 Godfrey 等人（2017 年）的研究表明，底物蛋白的固有特性也有贡献：好的激酶底物往往被早期磷酸化，而好的磷酸酶底物往往被晚期磷酸化。