Denhardt David T
Division of Life Sciences, Rutgers University, New Brunswick, New Jersey.
J Cell Physiol. 2018 Mar;233(3):1975-1984. doi: 10.1002/jcp.25837. Epub 2017 Apr 27.
I present a brief introduction to epigenetics, focused primarily on methylation of the genome and various regulatory RNAs, modifications of associated histones, and their importance in enabling us to adapt to real and changing environmental, developmental, and social circumstances. Following this is a more extensive overview of how it impacts our inheritance, our entire life (which changes as we age), and how we interact with others. Throughout, I emphasize the critical influence that stress, of many varieties exerts, via epigenetic means, on much of how we live and survive, mostly in the brain. I end with a short section on multigenerational transmission, drugs, and the importance of both social life and early life experiences in the development of adult diseases. There will be nothing about cancer. Although epigenetics is critical in that field, it is a whole different cobweb of complications (some involving stress).
我将简要介绍表观遗传学，主要聚焦于基因组甲基化、各种调控RNA、相关组蛋白的修饰，以及它们在使我们能够适应真实且不断变化的环境、发育和社会环境方面的重要性。接下来会更广泛地概述表观遗传学如何影响我们的遗传、我们的整个人生（随着年龄增长而变化）以及我们与他人的互动方式。在整个过程中，我强调多种形式的压力通过表观遗传方式对我们的生活和生存方式（主要在大脑中）产生的关键影响。最后我会简短地介绍一下多代遗传、药物，以及社交生活和早期生活经历在成人疾病发展中的重要性。本文不会涉及癌症相关内容。尽管表观遗传学在该领域至关重要，但它是一个完全不同的复杂网络（有些涉及压力）。
