Kageyama Shinji, Beppu Masanori, Ohnogi Hiromu, Miyazaki Sayaka, Haruno Akihiro, Ito Yoshihiko, Yamada Shizuo
Kageyama Urology Clinic, Shizuoka, Japan.
Beppu Nephrology and Urology Clinic, Shizuoka, Japan.
Low Urin Tract Symptoms. 2018 May;10(2):167-174. doi: 10.1111/luts.12155. Epub 2017 Feb 4.
To evaluate changes over time in subjective symptom scores and urination parameters before and after oral administration of formulated food containing a combination of Peucedanum japonicum (P. japonicum) extract and saw palmetto extract (SPE) in male patients with lower urinary tract symptoms (LUTS).
This study was conducted in an open label manner on male patients with untreated LUTS. The urination state of patients was evaluated before and after administration of food formulated with P. japonicum extract and SPE for 4 weeks, based on urodynamic parameters and subjective symptom scores (International Prostate Symptom Score [IPSS and IPSS-QOL], Overactive Bladder Symptom Score [OABSS], Overactive Bladder Questionnaire [OAB-q], and International Index of Erectile Function [IIEF]).
After the administration of food formulated with these extracts, the following results were obtained: (i) Subjective findings: The IPSS-QOL score improved significantly; both parameters related to nocturia, i.e., frequency of nighttime urination and OABSS-2, improved significantly; other ratings for subjective symptoms slightly improved. (ii) Objective findings: Residual urine volume decreased significantly, and blood prostate specific antigen (PSA) and urinary 8-OHdG levels decreased slightly after the treatment. (iii) Other findings: Blood pressure decreased slightly. No adverse drug reactions were reported. (iv) Patient impressions: 75% of patients gave a rating of "Good" or higher, with 15 out of 20 patients wanting to continue treatment after the end of 4-week administration period.
Food formulated with P. japonicum extract and SPE may be useful to decrease frequency of nighttime urination and residual urine volume in male patients with LUTS.
评估口服含有日本前胡（P. japonicum）提取物和锯棕榈提取物（SPE）组合的配方食品前后，男性下尿路症状（LUTS）患者主观症状评分和排尿参数随时间的变化。
本研究以开放标签方式对未经治疗的LUTS男性患者进行。基于尿动力学参数和主观症状评分（国际前列腺症状评分[IPSS和IPSS-QOL]、膀胱过度活动症症状评分[OABSS]、膀胱过度活动症问卷[OAB-q]和国际勃起功能指数[IIEF]），评估患者在服用含日本前胡提取物和SPE的配方食品4周前后的排尿状态。
服用这些提取物配方的食品后，获得了以下结果：（i）主观结果：IPSS-QOL评分显著改善；与夜尿相关的两个参数，即夜间排尿频率和OABSS-2，显著改善；主观症状的其他评分略有改善。（ii）客观结果：残余尿量显著减少，治疗后血液前列腺特异性抗原（PSA）和尿液8-OHdG水平略有下降。（iii）其他结果：血压略有下降。未报告药物不良反应。（iv）患者印象：75%的患者给出了“良好”或更高的评分，20名患者中有15名希望在4周给药期结束后继续治疗。
含有日本前胡提取物和SPE的配方食品可能有助于减少男性LUTS患者的夜间排尿频率和残余尿量。
