Kumar Naveen, Barua Sanjay, Riyesh Thachamvally, Tripathi Bhupendra N
National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, Haryana, India.
National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, Haryana, India.
Vet Microbiol. 2017 Jul;206:91-101. doi: 10.1016/j.vetmic.2017.01.010. Epub 2017 Jan 17.
Peste des petits ruminants (PPR) is a highly contagious disease of small ruminants that leads to high morbidity and mortality thereby results in devastating economic consequences to the livestock industry. PPR is currently endemic across most parts of Asia and Africa, the two regions with the highest concentration of poor people in the world. Sheep and goats in particularly contribute significantly towards the upliftment of livelihood of the poor and marginal farmers in these regions. In this context, PPR directly affecting the viability of sheep and goat husbandry has emerged as a major hurdle in the development of these regions. The control of PPR in these regions could significantly contribute to poverty alleviation, therefore, the Office International des Epizooties (OIE) and Food and Agricultural Organization (FAO) have targeted the control and eradication of PPR by 2030 a priority. In order to achieve this goal, a potent, safe and efficacious live-attenuated PPR vaccine with long-lasting immunity is available for immunoprophylaxis. However, the live-attenuated PPR vaccine is thermolabile and needs maintenance of an effective cold chain to deliver into the field. In addition, the infected animals cannot be differentiated from vaccinated animals. To overcome these limitations, some recombinant vaccines have been developed. This review comprehensively describes about the latest developments in PPR vaccines.
小反刍兽疫(PPR)是小反刍动物的一种高度传染性疾病,会导致高发病率和高死亡率,从而给畜牧业带来毁灭性的经济后果。目前,PPR在亚洲和非洲的大部分地区流行,这两个地区是世界上贫困人口最集中的地区。特别是绵羊和山羊对这些地区贫困和边缘农民的生计改善做出了重大贡献。在这种背景下,直接影响绵羊和山羊养殖可行性的PPR已成为这些地区发展的一个主要障碍。在这些地区控制PPR可显著促进减贫,因此,国际兽疫局(OIE)和粮食及农业组织(FAO)已将到2030年控制和根除PPR作为一项优先任务。为实现这一目标,有用于免疫预防的高效、安全且有效的具有持久免疫力的减毒活PPR疫苗。然而,减毒活PPR疫苗对热不稳定,需要维持有效的冷链才能投入使用。此外,无法区分感染动物和接种疫苗的动物。为克服这些局限性,已研发出一些重组疫苗。本综述全面描述了PPR疫苗的最新进展。