由无臭异氰基取代的鏻盐引发的 Ugi-3CR/Wittig 反应的一锅法吲哚合成。
One-Pot Synthesis of Indoles by a Sequential Ugi-3CR/Wittig Reaction Starting from Odorless Isocyanide-Substituted Phosphonium Salts.
机构信息
Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University , Wuhan 430079, People's Republic of China.
出版信息
J Org Chem. 2017 Mar 3;82(5):2772-2776. doi: 10.1021/acs.joc.7b00004. Epub 2017 Feb 10.
PMID:28161949
Abstract
A new one-pot preparation of indoles by a Ugi-3CR/Wittig sequence has been developed. The reaction of odorless isocyanide-substituted phosphonium salt 5, aldehyde 6, and amine 7 produced the indoles 9 in 45-82% yields via a sequential Ugi-3CR/Wittig reaction in the presence of HPO and solid KCO, respectively.
摘要
开发了一种通过 Ugi-3CR/Wittig 序列的新型吲哚一锅法制备方法。在 HPO 和固体 KCO 的存在下，无臭异氰酸酯取代的鏻盐 5、醛 6 和胺 7 反应分别以 45-82%的收率生成吲哚 9，通过顺序的 Ugi-3CR/Wittig 反应。
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