通过基于异腈的多组分/维蒂希顺序反应一锅法合成1H-异苯并呋喃和1,2-二氢异喹啉。
One-pot synthesis of 1H-isochromenes and 1,2-dihydroisoquinolines by a sequential isocyanide-based multicomponent/Wittig reaction.
作者信息
Wang Long, Guan Zhi-Rong, Ding Ming-Wu
机构信息
Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, P. R. China.
出版信息
Org Biomol Chem. 2016 Feb 28;14(8):2413-20. doi: 10.1039/c5ob02405f.
PMID:26810599
Abstract
A one-pot synthesis of 1H-isochromenes and 1,2-dihydroisoquinolines by a I-MCR/Wittig sequence was developed. The reaction of phosphonium salt , an acid, an amine (or without), and an isocyanide gave the 1H-isochromenes or 1,2-dihydroisoquinolines in good yields by a sequential Passerini or Ugi condensation and an intramolecular Wittig reaction in the presence of K2CO3.
摘要
通过I-MCR/维蒂希反应序列实现了1H-异苯并呋喃和1,2-二氢异喹啉的一锅法合成。鏻盐、一种酸、一种胺（或无胺）和异腈反应，在碳酸钾存在下，通过连续的帕塞里尼或乌吉缩合以及分子内维蒂希反应，以良好的产率得到1H-异苯并呋喃或1,2-二氢异喹啉。
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