Xie X R, Qin C, Chen L, Cheng D B, Huang J Y, Wei X X, Yu L X, Liang Z J
Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Zhonghua Nei Ke Za Zhi. 2017 Feb 1;56(2):99-103. doi: 10.3760/cma.j.issn.0578-1426.2017.02.004.
To explore the risk factors for lung cancer-related cerebral infarction. The hospitalized active lung cancer patients on anti-cancer therapy with no traditional stroke risk factors, who experienced an acute cerebral infarct in the First Affiliated Hospital of Guangxi Medical University from January 2005 to December 2015, were consecutively collected as the LCRS (lung cancer-related stroke) group. The active lung cancer patients without cerebral infarction hospitalized at the same peroid matched with the LCRS group for age and gender were collected as the LC (lung cancer) group. Clinical data from the two groups were analyzed. A total of 139 LCRS patients and 139 LC patients were enrolled in the study, with 110 male and 29 female in each group, and there were no significant difference for the mean age between the LCRS group (52.1±10.4 years old ) and the LC group (52.1±10.1 years old). Two or more acute ischemic lesions of the brain were showed by MRI in most patients in the LCRS group (117 cases, 84.2%). Compared with the LC group, more patients in the LCRS group were found with adenocarcinoma, metastasis, elevated plasma D-dimer, CA125 and CA199 levels [88 cases (63.3%) vs 47 cases (33.8%); 98 cases (70.5%) vs 56 cases (40.3%); (468.38±291.37) μg/L vs (277.59±191.22) μg/L; (221.42±146.34) U/ml vs (106.84±69.97) U/ml; (254.68±185.84) U/ml vs (97.15±63.64) U/ml; with all <0.001]. By logistic regression analysis of multiple factors, the elevated plasma D-dimer, CA125 and CA199 levels were showed to be independent risk factors for the cerebral infarction (=1.003, 95% 1.001-1.004; =1.006, 95% 1.003-1.010; =1.011, 95% 1.007-1.015). The elevated plasma D-dimer, CA125 and CA199 levels are the risk factors for the lung cancer related cerebral infarction, which may lead to hypercoagulation and induce cerebral infarction eventually.
探讨肺癌相关性脑梗死的危险因素。连续收集2005年1月至2015年12月在广西医科大学第一附属医院住院的、正在接受抗癌治疗且无传统卒中危险因素、发生急性脑梗死的活动性肺癌患者作为肺癌相关性卒中（LCRS）组。收集同期住院的、年龄和性别与LCRS组相匹配的无脑梗死的活动性肺癌患者作为肺癌（LC）组。分析两组的临床资料。本研究共纳入139例LCRS患者和139例LC患者，每组男性110例，女性29例，LCRS组（52.1±10.4岁）与LC组（52.1±10.1岁）的平均年龄无显著差异。LCRS组大多数患者（117例，84.2%）的MRI显示脑内有两个或更多急性缺血性病灶。与LC组相比，LCRS组更多患者患有腺癌、发生转移、血浆D-二聚体、CA125和CA199水平升高[88例（63.3%）对47例（33.8%）；98例（70.5%）对56例（40.3%）；（468.38±291.37）μg/L对（277.59±191.22）μg/L；（221.42±146.34）U/ml对（106.84±69.97）U/ml；（254.68±185.84）U/ml对（97.15±63.64）U/ml；均P<0.001]。多因素logistic回归分析显示，血浆D-二聚体、CA125和CA199水平升高是脑梗死的独立危险因素（β=1.003，95%CI 1.001-1.004；β=1.006，95%CI 1.
