Xie Xingrui, Chen Li, Zeng Jinsheng, Qin Chao, Cheng Daobin, Wei Xinxian, Liang Zhijian
1 Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
2 Department of Neurology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
J Int Med Res. 2016 Dec;44(6):1483-1491. doi: 10.1177/0300060516666398. Epub 2016 Nov 10.
Objective To identify the unique clinical features and biological markers of lung cancer-associated stroke. Methods We recruited 102 patients with lung cancer plus stroke, 102 with lung cancer, and 102 with stroke. Detailed information was analysed and compared among groups. Results The groups were age-matched. Patients with lung cancer plus stroke showed multiple lesions involving multiple cerebral artery territories on magnetic resonance imaging, compared with stroke-alone patients. These patients also had a poorer modified Rankin Scale score at 30 days, and high mortality (18.6%). Patients with lung cancer plus stroke had a higher incidence of metastasis, and higher blood levels of D-dimer, CA125 and CA199 compared with patients with lung cancer alone. Multivariate logistic regression analysis showed that levels of D-dimer, CA125 and CA199 were independently related to lung cancer-associated stroke. Conclusion Elevated plasma D-dimer, CA125 and CA199 may be independent risk factors for and biomarkers of lung cancer-associated stroke.
目的 确定肺癌相关性卒中的独特临床特征和生物学标志物。方法 我们招募了102例肺癌合并卒中患者、102例肺癌患者和102例卒中患者。对各组的详细信息进行分析和比较。结果 各组年龄匹配。与单纯卒中患者相比，肺癌合并卒中患者在磁共振成像上显示出累及多个脑动脉区域的多处病变。这些患者在30天时改良Rankin量表评分也较差，且死亡率较高（18.6%）。与单纯肺癌患者相比，肺癌合并卒中患者转移发生率更高，D-二聚体、CA125和CA199的血液水平更高。多因素逻辑回归分析显示，D-二聚体、CA125和CA199水平与肺癌相关性卒中独立相关。结论 血浆D-二聚体、CA125和CA199升高可能是肺癌相关性卒中的独立危险因素和生物学标志物。
