Calvo R, Aguilera L, Suárez E, Rodriguez-Sasiaín J M
Department of Pharmacology, University of Basque Country, Leioa, Spain.
Acta Anaesthesiol Scand. 1989 Oct;33(7):575-7. doi: 10.1111/j.1399-6576.1989.tb02969.x.
The in vitro effects of the halothane metabolite, trifluoroacetic acid, on the binding of warfarin to human serum proteins have been investigated. An increase in the percentage of free warfarin following incubation with different concentrations of trifluoroacetic acid (1 and 4 mmol/l) was observed. In addition, protein binding of warfarin was studied in serum from patients undergoing halothane anaesthesia (1-2.5%; 2.5 h). After 24 h from the end of the halothane anaesthesia, an increase in the percentage of free warfarin was also detected (0.92 +/- 0.06% at 24 h vs 0.60 +/- 0.02% before halothane administration; P less than 0.005). We conclude that halothane anaesthesia may temporarily potentiate the pharmacological effect of warfarin in the postoperative period following anaesthetic procedures.
已对氟烷代谢产物三氟乙酸对华法林与人血清蛋白结合的体外效应进行了研究。观察到在与不同浓度的三氟乙酸（1和4 mmol/l）孵育后，游离华法林的百分比增加。此外，还研究了接受氟烷麻醉（1 - 2.5%；2.5小时）患者血清中华法林的蛋白结合情况。在氟烷麻醉结束24小时后，也检测到游离华法林的百分比增加（24小时时为0.92±0.06%，而氟烷给药前为0.60±0.02%；P＜0.005）。我们得出结论，氟烷麻醉可能在麻醉手术后短期内增强华法林的药理作用。
