Reves J G, McCracken L E
Br J Anaesth. 1976 May;48(5):419-24. doi: 10.1093/bja/48.5.419.
The aetiology of the rare hepatic failure following halothane anaesthesia is not known. In an attempt to develop an experimental model, three groups of guineapigs were exposed to air or oxygen, a single 1% halothane administration, or five exposures of 1% halothane at weekly intervals. In an attempt to identify a hypersensitivity reaction, all animals were skin-tested with the common final metabolite of halothane, fluroxene and isoflurane: trifluoroacetic acid, prepared as a complex with autologous serum protein. Hepatic necrosis was found in all groups and did not correlate with positive skin reactions. There was an increase in fatty changes in the liver in animals anaesthetized with halothane.
氟烷麻醉后罕见的肝衰竭病因尚不清楚。为了建立一个实验模型，将三组豚鼠分别暴露于空气或氧气、单次给予1%氟烷、或每周一次共五次给予1%氟烷。为了确定超敏反应，所有动物均用氟烷的常见终末代谢产物氟烯和异氟烷：三氟乙酸（与自体血清蛋白形成复合物制备）进行皮肤试验。所有组均发现肝坏死，且与皮肤反应阳性无关。用氟烷麻醉的动物肝脏脂肪变性增加。
