胚胎发育过程中维持生殖细胞库需要CDK5RAP2。

Zaqout Sami, Bessa Paraskevi, Krämer Nadine, Stoltenburg-Didinger Gisela, Kaindl Angela M

Institute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Center for Chronically Sick Children (Sozialpädiatrisches Zentrum, SPZ), Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany; Berlin Institute of Health (BIH), Kapelle-Ufer 2, 10117 Berlin, Germany.

Institute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Stem Cell Reports. 2017 Feb 14;8(2):198-204. doi: 10.1016/j.stemcr.2017.01.002. Epub 2017 Feb 2.

Gene products linked to microcephaly have been studied foremost for their role in brain development, while their function in the development of other organs has been largely neglected. Here, we report the critical role of Cdk5rap2 in maintaining the germ cell pool during embryonic development. We highlight that infertility in Cdk5rap2 mutant mice is secondary to a lack of spermatogenic cells in adult mice as a result of an early developmental defect in the germ cells through mitotic delay, prolonged cell cycle, and apoptosis.

与小头畸形相关的基因产物主要因其在大脑发育中的作用而被研究，而它们在其他器官发育中的功能在很大程度上被忽视了。在这里，我们报告了Cdk5rap2在胚胎发育过程中维持生殖细胞池的关键作用。我们强调，Cdk5rap2突变小鼠的不育是成年小鼠缺乏生精细胞的继发结果，这是由于生殖细胞在发育早期出现有丝分裂延迟、细胞周期延长和凋亡等缺陷所致。