Resch Bernhard, Egger Beatrice, Kurath-Koller Stefan, Urlesberger Berndt
Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Austria; Research Unit for Neonatal Infectious Diseases and Epidemiology, Medical University of Graz, Austria.
Research Unit for Neonatal Infectious Diseases and Epidemiology, Medical University of Graz, Austria.
Int J Infect Dis. 2017 Apr;57:50-53. doi: 10.1016/j.ijid.2017.01.034. Epub 2017 Feb 2.
To obtain data on respiratory syncytial virus (RSV) associated hospitalization rates in preterm infants of 28 weeks gestational age and less in the era of palivizumab prophylaxis.
Retrospective single-center cohort study including all preterm infants up to 28 weeks+6days gestational age and born between 2004 and 2012 at a tertiary care university hospital. Data on RSV related hospitalizations over the first two years of life covering at least two RSV seasons (November-April) were analyzed.
Ninety-one of 287 (32%) infants were hospitalized due to respiratory illness, and a total of 17 infants (5.9%) tested RSV positive during the first 2 years of life. Fourteen infants (4.9%) were hospitalized during the first RSV season. RSV hospitalization rate in infants with BPD was 4.5% (2/44) compared to 4.9% (12/243) without BPD. Palivizumab prophylaxis was documented in 74.6% of the infants. Infants with RSV compared to other respiratory tract infection were of younger age (6.8 vs. 9.1 months; p=0.049), had longer hospital stays (median 11 vs. 5 days; p=0.043) and more severe respiratory illness (median LRI score 3 vs. 2; p=0.043).
Despite palivizumab prophylaxis the burden of RSV disease and all cause respiratory illness was still remarkable in this vulnerable preterm population and mainly limited to the first season.
获取在帕利珠单抗预防时代，胎龄28周及以下早产儿呼吸道合胞病毒（RSV）相关住院率的数据。
回顾性单中心队列研究，纳入2004年至2012年在一所三级护理大学医院出生的所有胎龄达28周+6天的早产儿。分析出生后头两年内至少涵盖两个RSV季节（11月至4月）的RSV相关住院数据。
287名婴儿中有91名（32%）因呼吸道疾病住院，在出生后头两年内共有17名婴儿（5.9%）RSV检测呈阳性。14名婴儿（4.9%）在第一个RSV季节住院。患有支气管肺发育不良（BPD）的婴儿RSV住院率为4.5%（2/44），未患BPD的婴儿为4.9%（12/243）。74.6%的婴儿有帕利珠单抗预防的记录。与其他呼吸道感染的婴儿相比，感染RSV的婴儿年龄更小（6.8个月对9.1个月；p=0.049），住院时间更长（中位数11天对5天；p=0.043），呼吸道疾病更严重（中位数下呼吸道感染评分3对2；p=0.043）。
尽管有帕利珠单抗预防，RSV疾病负担和所有病因的呼吸道疾病在这一脆弱的早产人群中仍然显著，且主要局限于第一个季节。
