Grover Sandeep, Mehra Aseem, Chakrabarti Subho, Avasthi Ajit
Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
J Neurosci Rural Pract. 2016 Dec;7(Suppl 1):S7-S12. doi: 10.4103/0976-3147.196440.
This study aims to evaluate the cognitive functions of patients with delirium using Hindi Mental Status Examination (HMSE), to study the correlation of cognitive functions assessed by HMSE with noncognitive symptoms as assessed using Delirium Rating Scale-Revised 1998 (DRS-R-98) and to study the association of cognitive functions assessed using HMSE and DRS-R98.
A total of 76 consecutive patients fulfilling the diagnosis of delirium were evaluated on DRS-R-98, HMSE, and Short Informant Questionnaire on Cognitive Decline in the Elderly (retrospective IQCODE).
The mean DRS-R-98 score 33.9 (standard deviation [SD] - 7.2) and the mean DRS-R-98 severity score was 25.9 (SD - 7.2). The mean score on HMSE was 19.3 (7.98). There were significant correlations of all the domains of HMSE with DRS-R-98 total score, DRS-R-98 severity score, DRS-R-98 cognitive subscale score, DRS-R-98 noncognitive domain subscale score, and DRS severity score without attention score. When the association of each item of DRS-R-98 and HMSE was evaluated, except for the items of delusions, lability of affect and motor retardation, there were significant negative association between all the items of DRS-R-98 and HMSE, indicating that higher severity of cognitive symptoms as assessed on HMSE is associated with higher severity of all the cognitive symptoms and most of the noncognitive symptoms as assessed by DRS-R-98.
The present study suggests that attention deficits in patients with delirium influence the severity of cognitive and noncognitive symptoms of delirium. Further, the present study suggests an increase in the severity of cognitive symptoms in other domains is also associated with an increase in the severity of noncognitive symptoms of delirium.
本研究旨在使用印地语精神状态检查（HMSE）评估谵妄患者的认知功能，研究HMSE评估的认知功能与使用1998年修订的谵妄评定量表（DRS-R-98）评估的非认知症状之间的相关性，并研究使用HMSE和DRS-R98评估的认知功能之间的关联。
对76例连续符合谵妄诊断的患者进行DRS-R-98、HMSE和老年人认知衰退简短知情者问卷（回顾性IQCODE）评估。
DRS-R-98平均得分为33.9（标准差[SD]-7.2），DRS-R-98严重程度平均得分为25.9（SD-7.2）。HMSE平均得分为19.3（7.98）。HMSE的所有领域与DRS-R-98总分、DRS-R-98严重程度得分、DRS-R-98认知子量表得分、DRS-R-98非认知领域子量表得分以及无注意力得分的DRS严重程度得分均存在显著相关性。当评估DRS-R-98和HMSE的每个项目之间的关联时，除了妄想、情感不稳定和运动迟缓项目外，DRS-R-98的所有项目与HMSE之间均存在显著负相关，表明HMSE评估的认知症状严重程度越高，DRS-R-98评估的所有认知症状和大多数非认知症状的严重程度越高。
本研究表明，谵妄患者的注意力缺陷会影响谵妄的认知和非认知症状的严重程度。此外，本研究表明，其他领域认知症状严重程度的增加也与谵妄非认知症状严重程度的增加有关。
