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Effect of recombinant human growth hormone therapy on bone and clinical parameters in girls with Turner's syndrome. The Spanish Collaborative Group.

作者信息

Ferrández A, Mayayo E, Arnal J M, García C, Buñuel C, Lasarte J J, Anton R, Puyuelo P

机构信息

Endocrine Unit, Children's Hospital, Zaragoza, Spain.

出版信息

Acta Paediatr Scand Suppl. 1989;356:87-91; discussion 92. doi: 10.1111/j.1651-2227.1989.tb11254.x.

DOI:10.1111/j.1651-2227.1989.tb11254.x
PMID:2816362
Abstract

Forty-eight girls with Turner's syndrome were assigned to one of three treatments; recombinant human growth hormone (rhGH) alone, rhGH plus oxandrolone, and rhGH plus ethinyloestradiol. Treatment with rhGH alone or in combination with oxandrolone induced catch-up growth. Older girls treated with rhGH plus ethinyloestradiol showed less marked improvement. The gain in height was associated with a gain in bone diameter and cortical thickness (reflecting increased bone mass). There was a rapid loss of subcutaneous fat. These effects of growth hormone are similar to those observed in patients with growth hormone deficiency.

摘要

相似文献

1
Effect of recombinant human growth hormone therapy on bone and clinical parameters in girls with Turner's syndrome. The Spanish Collaborative Group.
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2
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[The effects of treatment with growth hormone alone or in combination with oxandrolone in a group of Turner's syndrome children. A preliminary study].[生长激素单独治疗或与氧雄龙联合治疗一组特纳综合征儿童的效果。一项初步研究]
Minerva Pediatr. 1991 Jun;43(6):465-9.

引用本文的文献

1
Oxandrolone for growth hormone-treated girls aged up to 18 years with Turner syndrome.氧雄龙用于治疗18岁及以下患有特纳综合征且接受生长激素治疗的女孩。
Cochrane Database Syst Rev. 2019 Oct 30;2019(10):CD010736. doi: 10.1002/14651858.CD010736.pub2.
2
Optimum use of growth hormone in children.
Drugs. 1991 Jul;42(1):1-8. doi: 10.2165/00003495-199142010-00001.