Chen Hongbo, Tao Feng, Fang Xiangdong, Wang Xietong
Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, China; Department of Obstetrics and Gynecology and Anesthesiology, Maternal and Child Health Hospital, Anhui Province, Hefei, China.
Department of Obstetrics and Gynecology and Anesthesiology, Maternal and Child Health Hospital, Anhui Province, Hefei, China.
J Res Med Sci. 2016 Nov 2;21:98. doi: 10.4103/1735-1995.193170. eCollection 2016.
The aim of this study was to evaluate maternal and perinatal outcomes in preeclampsia (PE), according to the value of albumin.
Preeclamptic women were retrospectively divided into mild hypoproteinemia (MHP, = 220) and severe hypoproteinemia (SHP, = 79) PE according to the value of albumin. The maternal and perinatal outcomes were evaluated in both groups.
Two hundred and ninety-nine single pregnancies complicated by PE were included in this study. Gestational age at delivery was earlier in SHP than MHP ( < 0.01). Severe hypertension, abnormal liver function, abnormal renal function, ascites, and abruption occurred more frequently in SHP than in MHP (< 0.01, 0.03, <0.01, 0.01, and 0.04, respectively). Women in SHP had a higher rate of cesarean section than those in MHP ( = 0.04). Fetal growth restriction infants were more frequent in SHP than in MHP ( < 0.01). The occupancy rate of the Neonatal Intensive Care Unit was higher in SHP than in MHP ( < 0.01).
SHP PE is associated with a higher risk of adverse pregnancy outcome than MHP PE, deserving closer surveillance during pregnancy.
本研究旨在根据白蛋白值评估子痫前期（PE）患者的孕产妇及围产儿结局。
根据白蛋白值，将子痫前期患者回顾性分为轻度低蛋白血症（MHP，n = 220）和重度低蛋白血症（SHP，n = 79）子痫前期两组。对两组的孕产妇及围产儿结局进行评估。
本研究纳入299例单胎妊娠合并子痫前期患者。SHP组的分娩孕周早于MHP组（P < 0.01）。SHP组重度高血压、肝功能异常、肾功能异常、腹水及胎盘早剥的发生率高于MHP组（分别为P < 0.01、0.03、P < 0.01、P < 0.01及0.04）。SHP组剖宫产率高于MHP组（P = 0.04）。SHP组胎儿生长受限婴儿的发生率高于MHP组（P < 0.01）。SHP组新生儿重症监护病房入住率高于MHP组（P < 0.01）。
与MHP子痫前期相比，SHP子痫前期不良妊娠结局风险更高，孕期值得密切监测。
