Güler Mete, Türkçüoğlu Peykan, Yılmaz Turgut, Yoldaş Tahir Kurtuluş, Channa Roomasa
Department of Ophthalmology, School of Medicine, Adıyaman University Adıyaman Turkey.
Department of Ophthalmology, Göznuru Eye Hospital Gaziantep Turkey.
Neuroophthalmology. 2013 Mar 22;37(2):58-62. doi: 10.3109/01658107.2013.767356. eCollection 2013.
This study compared the visual field parameters of multiple sclerosis patients without optic neuritis in early versus advanced stage of the disease. Patients were divided into two groups: group 1 (early stage, = 14) constituted of patients with Expanded Disability Status Scale scores <3 and group 2 (advanced stage, = 13) constituted of patients with Expanded Disability Status Scale scores ≥3. Mean visual acuities in both groups were similar ( = 0.674). Mean sensitivity, mean defect, loss of variance, reliability factor parameters (Octopus 101 perimeter) of groups 1 and 2 were 24.17 ± 3.62, 21.81 ± 3.04; 4.14 ± 3.05, 6.49 ± 2.58; 21.61 ± 22.17, 33.31 ± 18.67; and 1.57 ± 2.79, 2.59 ± 3.09, respectively. Compared with group 1, mean sensitivity was significantly lower in group 2 ( = 0.013). Mean defect ( = 0.004) and loss of variance ( = 0.042) parameters in group 2 were significantly higher than in group 1. Mean reliability factor was similar between two groups ( = 0.211). Multiple scleorisis may alter visual field parameters without severe loss of visual acuity by possibly involving optic pathways other than optic nerve.
本研究比较了未患视神经炎的多发性硬化症患者疾病早期与晚期的视野参数。患者被分为两组：第1组（早期，n = 14）由扩展残疾状态量表评分<3的患者组成，第2组（晚期，n = 13）由扩展残疾状态量表评分≥3的患者组成。两组的平均视力相似（n = 0.674）。第1组和第2组的平均敏感度、平均缺损、方差损失、可靠性因子参数（Octopus 101视野计）分别为24.17±3.62、21.81±3.04；4.14±3.05、6.49±2.58；21.61±22.17、33.31±18.67；以及1.57±2.79、2.59±3.09。与第1组相比，第2组的平均敏感度显著更低（p = 0.013）。第2组的平均缺损（p = 0.004）和方差损失（p = 0.042）参数显著高于第1组。两组之间的平均可靠性因子相似（p = 0.211）。多发性硬化症可能通过累及除视神经之外的其他视路，在不严重丧失视力的情况下改变视野参数。
