García-Suástegui W A, Ramos-Chávez L A, Rubio-Osornio M, Calvillo-Velasco M, Atzin-Méndez J A, Guevara J, Silva-Adaya D
Departamento de Biología y Toxicología de la Reproducción, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, 72000 Heroica Puebla de Zaragoza, PUE, Mexico.
Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, 70228 Mexico City, Mexico.
Oxid Med Cell Longev. 2017;2017:4680732. doi: 10.1155/2017/4680732. Epub 2017 Jan 10.
Organisms have metabolic pathways that are responsible for removing toxic agents. We always associate the liver as the major organ responsible for detoxification of the body; however this process occurs in many tissues. In the same way, as in the liver, the brain expresses metabolic pathways associated with the elimination of xenobiotics. Besides the detoxifying role of CYP2E1 for compounds such as electrophilic agents, reactive oxygen species, free radical products, and the bioactivation of xenobiotics, CYP2E1 is also related in several diseases and pathophysiological conditions. In this review, we describe the presence of phase I monooxygenase CYP2E1 in regions of the brain. We also explore the conditions where protein, mRNA, and the activity of CYP2E1 are induced. Finally, we describe the relation of CYP2E1 in brain disorders, including the behavioral relations for alcohol consumption via CYP2E1 metabolism.
生物体拥有负责清除有毒物质的代谢途径。我们总是将肝脏视为负责身体解毒的主要器官；然而，这个过程在许多组织中都会发生。同样，就像在肝脏中一样，大脑也表达与外源性物质清除相关的代谢途径。除了CYP2E1对亲电试剂、活性氧、自由基产物等化合物的解毒作用以及对外源性物质的生物活化作用外，CYP2E1还与多种疾病和病理生理状况有关。在这篇综述中，我们描述了大脑区域中I相单加氧酶CYP2E1的存在情况。我们还探讨了CYP2E1的蛋白质、mRNA和活性被诱导的条件。最后，我们描述了CYP2E1与脑部疾病的关系，包括通过CYP2E1代谢与酒精消费的行为关系。
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