孟加拉人群中[具体基因名称1]和[具体基因名称2]基因变异与精神分裂症的关联：一项病例对照研究。 （你提供的原文中“Association of and ”这里有缺失信息，我按照常规推测补充了[具体基因名称1]和[具体基因名称2]，你可根据实际情况修改。）
Association of and Genetic Variants With Schizophrenia in the Bangladeshi Population: A Case-Control Study.
作者信息
Millat Md Shalahuddin, Roy Joysree, Rahman Md Atikur, Aziz Md Abdul, Islam Safiqul, Chowdhury Md Mazharul Islam, Barek Md Abdul, Hussain Md Saddam, Uddin Mohammad Sarowar, Siddiqui Shafayet Ahmed, Islam Mohammad Safiqul
机构信息
Department of Pharmacy Noakhali Science and Technology University Sonapur Noakhali Bangladesh.
Laboratory of Pharmacogenomics and Molecular Biology, Department of Pharmacy Noakhali Science and Technology University Sonapur Noakhali Bangladesh.
出版信息
Health Sci Rep. 2024 Dec 17;7(12):e70262. doi: 10.1002/hsr2.70262. eCollection 2024 Dec.
BACKGROUND AND AIMS
Schizophrenia (SCZ) is among the most persistent and devastating psychological problems. Different genetic polymorphisms are responsible for the predisposition of SCZ, and we screened (rs2071287, rs204993) and (rs2070673) polymorphisms in this study to find the connection with SCZ development.
METHODS
We investigated a total of 420 samples (210 patients and 210 controls) and used the PCR-RFLP technique to genotype all SNPs. For statistical analyses, SPSS (version 25.0) was applied.
RESULTS
In the case of rs2071287, no evidence of a link was found in any genetic models, whereas rs204993 and rs2070673 showed a significant linkage in four genetic models with SCZ risk (for rs204993, additive model 2: OR = 3.39, CI = 1.84-6.23, = 0.0001; dominant: OR = 1.84, CI = 1.22-2.76, = 0.0032; recessive: OR = 2.67, CI = 1.53-4.64, = 0.0005; allelic: OR = 1.75, CI = 1.32-2.30, = 0.0001 and for rs2070673, additive model 2: OR = 0.39, CI = 0.22-0.69, = 0.0013; recessive: OR = 0.45, CI = 0.29-0.68, = 0.0002; overdominant: OR = 1.49, CI = 1.02-2.19, = 0.0408; allelic: OR = 0.61, CI = 0.46-0.80, = 0.0004).
CONCLUSIONS
The findings of our study suggest that the polymorphisms rs204993 and rs2070673 in the Bangladeshi ethnicity are connected to the risk of SCZ.
背景与目的
精神分裂症（SCZ）是最持久且具破坏性的心理问题之一。不同的基因多态性导致了SCZ的易感性，在本研究中我们筛查了（rs2071287、rs204993）以及（rs2070673）多态性，以探寻其与SCZ发生发展的关联。
方法
我们共调查了420个样本（210例患者和210例对照），并使用聚合酶链反应 - 限制性片段长度多态性（PCR - RFLP）技术对所有单核苷酸多态性（SNP）进行基因分型。统计分析采用SPSS（25.0版）。
结果
对于rs2071287，在任何遗传模型中均未发现关联证据，而rs204993和rs2070673在四种遗传模型中显示出与SCZ风险存在显著关联（对于rs204993，加性模型2：比值比（OR）= 3.39，置信区间（CI）= 1.84 - 6.23，P = 0.0001；显性模型：OR = 1.84，CI = 1.22 - 2.76，P = 0.0032；隐性模型：OR = 2.67，CI = 1.53 - 4.64，P = 0.0005；等位基因模型：OR = 1.75，CI = 1.32 - 2.30，P = 0.0001；对于rs2070673，加性模型2：OR = 0.39，CI = 0.22 - 0.69，P = 0.0013；隐性模型：OR = 0.45，CI = 0.29 - 0.68，P = 0.0002；超显性模型：OR = 1.49，CI = 1.02 - 2.19，P = 0.0408；等位基因模型：OR = 0.61，CI = 0.46 - 0.80，P = 0.0004）。
结论
我们的研究结果表明，孟加拉族中的rs204993和rs2070673多态性与SCZ风险相关。
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