在血压正常的成年人群中，心血管代谢和心理因素对盐敏感性的影响程度如何？
How far cardio metabolic and psychological factors affect salt sensitivity in normotensive adult population?
作者信息
Sadeghi Masoumeh, Roohafza Hamidreza, Pourmoghaddas Masoud, Behnamfar Omid, Pourmoghaddas Zahra, Heidari Ebrahim, Mahjoor Zahra, Mousavi Mehdi, Bahonar Ahmad, Sarrafzadegan Nizal
机构信息
Masoumeh Sadeghi, Ebrahim Heidari, Mehdi Mousavi, Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan 8187698191, Iran.
出版信息
World J Cardiol. 2017 Jan 26;9(1):47-54. doi: 10.4330/wjc.v9.i1.47.
AIM
To evaluate the prevalence of salt sensitivity and the impact of cardiometabolic and psychological characteristics on salt sensitivity in normotensive population.
METHODS
Of all participants, anthropometric measurements and fasting venous blood samples were collected, and study questionnaires were completed. Salt Sensitivity was defined based on the difference in mean arterial pressure with infusion of 2 L of normal saline followed by a low sodium diet and administration of three doses of oral furosemide the day after.
RESULTS
Of 131 participants, 56 (42.7%) were diagnosed with salt sensitivity. Crude and age and sex adjusted regression analysis showed that low-density lipoprotein cholesterol and depression were positively associated with salt sensitivity (OR = 1.02, 95%CI: 1.01-1.04 and OR = 1.15, 95%CI: 1.00-1.34, respectively).
CONCLUSION
The high prevalence of salt sensitivity and its significant relation with prevalent risk factors necessitates considering its reduction actions at the population level and the need for further research.
目的
评估盐敏感性的患病率以及心血管代谢和心理特征对正常血压人群盐敏感性的影响。
方法
收集所有参与者的人体测量数据和空腹静脉血样本，并完成研究问卷。盐敏感性根据输注2升生理盐水后平均动脉压的差异来定义，随后进行低钠饮食，并在次日给予三剂口服速尿。
结果
在131名参与者中，56人（42.7%）被诊断为盐敏感性。粗回归分析以及年龄和性别校正后的回归分析表明，低密度脂蛋白胆固醇和抑郁与盐敏感性呈正相关（OR分别为1.02，95%CI：1.01 - 1.04和OR为1.15，95%CI：1.00 - 1.34）。
结论
盐敏感性的高患病率及其与常见危险因素的显著关系，使得有必要在人群层面考虑降低盐敏感性的措施，并进一步开展研究。
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