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信号转导和转录激活因子5与CD4 T细胞免疫

STAT5 and CD4 T Cell Immunity.

作者信息

Owen David L, Farrar Michael A

机构信息

Center for Immunology, Masonic Cancer Center, and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.

出版信息

F1000Res. 2017 Jan 11;6:32. doi: 10.12688/f1000research.9838.1. eCollection 2017.

DOI:10.12688/f1000research.9838.1
PMID:28163905
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5247784/
Abstract

STAT5 plays a critical role in the development and function of many cell types. Here, we review the role of STAT5 in the development of T lymphocytes in the thymus and its subsequent role in the differentiation of distinct CD4 helper and regulatory T-cell subsets.

摘要

信号转导及转录激活因子5（STAT5）在多种细胞类型的发育和功能中发挥着关键作用。在此，我们综述了STAT5在胸腺中T淋巴细胞发育过程中的作用及其随后在不同CD4辅助性T细胞和调节性T细胞亚群分化中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bace/5247784/b16f5af6b47a/f1000research-6-10607-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bace/5247784/58f9c3253214/f1000research-6-10607-g0000.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bace/5247784/b16f5af6b47a/f1000research-6-10607-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bace/5247784/58f9c3253214/f1000research-6-10607-g0000.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bace/5247784/b16f5af6b47a/f1000research-6-10607-g0001.jpg

相似文献

[1]
STAT5 and CD4 T Cell Immunity.

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[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[10]
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本文引用的文献

[1]
An essential role for the IL-2 receptor in T cell function.

Nat Immunol. 2016-11

[2]
Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.

Elife. 2016-3-21

[3]
STAT3 Impairs STAT5 Activation in the Development of IL-9-Secreting T Cells.

J Immunol. 2016-4-15

[4]
Genome-wide Analysis Identifies Bcl6-Controlled Regulatory Networks during T Follicular Helper Cell Differentiation.

Cell Rep. 2016-2-11

[5]
IL-7 signalling represses Bcl-6 and the TFH gene program.

Nat Commun. 2016-1-8

[6]
Immune homeostasis enforced by co-localized effector and regulatory T cells.

Nature. 2015-12-10

[7]
Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis.

Immunity. 2015-8-18

[8]
STAT5 Orchestrates Local Epigenetic Changes for Chromatin Accessibility and Rearrangements by Direct Binding to the TCRγ Locus.

J Immunol. 2015-8-15

[9]
The receptor NLRP3 is a transcriptional regulator of TH2 differentiation.

Nat Immunol. 2015-6-22

[10]
IFN-α/β receptor signaling promotes regulatory T cell development and function under stress conditions.

J Immunol. 2015-5-1

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