Feng Ye, Tang Yan, Zhou Hongwei, Xie Kaiqing
a Department of Blood Purification , The First Affiliated Hospital of Guangxi Medical University , Nanning , Guangxi , China.
Ren Fail. 2017 Nov;39(1):350-356. doi: 10.1080/0886022X.2017.1281146.
The level of interleukin-6 (IL-6) and its gene polymorphism are associated with the end-stage renal disease (ESRD) and the related complications. This study aimed to investigate the correction between IL-6 -174G/C polymorphism and ESRD by meta-analysis.
Using the databases including PubMed, Embase, Cochrane library, CNKI, and CBM, the data of case-control studies on correlation between IL-6 -174G/C polymorphism and ESRD from database establishment to January 2016 were collected. According to inclusion and exclusion criteria, the quality of literatures was evaluated. The relevant research data were extracted, followed by meta-analysis using Revman 5.3 software (London, UK). The combined odds ratio (OR) and 95% confidence interval (95%CI) of each genetic model were calculated, and the publication bias data was assessed using the Stata 12.0 software (College Station, TX).
A total of five literatures were included, with 1199 cases in case group and 1089 cases in control group. Meta-analysis showed that, there was no significant correlation between each genetic model of IL-6 -174G/C polymorphism and ESRD [(C versus G): OR = 1.36, 95%CI (0.69, 2.66), p = .38; (CC + GC versus GG): OR = 1.28, 95%CI (0.58, 2.82), p = .54; (CC versus GG + GC): OR = 1.71, 95%CI (0.82, 3.54), p = .15; (CC versus GG): OR = 1.74, 95%CI (0.76, 3.99), p = .19; (GC versus GG): OR = 1.18, 95%CI (0.55, 2.54), p = .67]. The race subgroup analysis showed that, there was no significant correlation between each genetic model of IL-6 -174G/C polymorphism and ESRD in the Caucasians (p > .05).
IL-6 -174G/C polymorphism has no significant correlation with the susceptibility risk of ESRD, and may not be a risk factor for ESRD.
白细胞介素-6（IL-6）水平及其基因多态性与终末期肾病（ESRD）及其相关并发症有关。本研究旨在通过荟萃分析探讨IL-6 -174G/C多态性与ESRD之间的关系。
利用PubMed、Embase、Cochrane图书馆、中国知网（CNKI）和中国生物医学文献数据库（CBM）等数据库，收集从数据库建立至2016年1月有关IL-6 -174G/C多态性与ESRD相关性的病例对照研究数据。根据纳入和排除标准对文献质量进行评价。提取相关研究数据，随后使用Revman 5.3软件（英国伦敦）进行荟萃分析。计算各遗传模型的合并比值比（OR）和95%置信区间（95%CI），并使用Stata 12.0软件（德克萨斯州大学站）评估发表偏倚数据。
共纳入5篇文献，病例组1199例，对照组1089例。荟萃分析显示，IL-6 -174G/C多态性各遗传模型与ESRD之间均无显著相关性[（C与G比较）：OR = 1.36，95%CI（0.69，2.66），p = 0.38；（CC + GC与GG比较）：OR = 1.28，95%CI（0.58，2.82），p = 0.54；（CC与GG + GC比较）：OR = 1.71，95%CI（0.82，3.54），p = 0.15；（CC与GG比较）：OR = 1.74，95%CI（0.76，3.99），p = 0.19；（GC与GG比较）：OR = 1.18，95%CI（0.55，2.54），p = 0.67]。种族亚组分析显示，在白种人中，IL-6 -174G/C多态性各遗传模型与ESRD之间均无显著相关性（p > 0.05）。
IL-6 -174G/C多态性与ESRD的易感性风险无显著相关性，可能不是ESRD的危险因素。
