Giannakakis Sotirios, Galyfos George, Sachmpazidis Ioannis, Kapasas Kostas, Kerasidis Stavros, Stamatatos Ioannis, Geropapas Georgios, Kastrisios Georgios, Papacharalampous Gerasimos, Maltezos Chrisostomos
Department of Vascular Surgery, KAT General Hospital, Athens, Greece.
Department of Vascular Surgery, KAT General Hospital, 2 Nikis Street, Kifisia, 14561, Athens, Greece.
Ther Adv Cardiovasc Dis. 2017 Apr;11(4):125-132. doi: 10.1177/1753944716687517. Epub 2017 Feb 5.
Peripheral artery disease (PAD) has been associated with severe morbidity and mortality worldwide, affecting the quality of life for millions of patients. Acute thrombosis has been identified as a major complication of PAD, with proper management including both open as well as endovascular techniques. Thrombolysis has emerged as a reasonable option in the last decades to treat such patients although data produced by randomized trials have been limited. This review aims to present major aspects of thrombolysis in PAD regarding its indications and contraindications, technique tips as well as to review literature data in order to produce useful conclusions for everyday clinical practice.
外周动脉疾病(PAD)在全球范围内都与严重的发病率和死亡率相关,影响着数百万患者的生活质量。急性血栓形成已被确认为PAD的主要并发症,其恰当的治疗包括开放手术和血管内技术。在过去几十年中,溶栓已成为治疗此类患者的一种合理选择,尽管随机试验所产生的数据有限。本综述旨在介绍PAD溶栓在其适应证和禁忌证、技术要点方面的主要内容,并回顾文献数据,以便为日常临床实践得出有用的结论。