Hunt Richard H, Yaghoobi Mohammad
Division of Gastroenterology and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Division of Gastroenterology and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Gastroenterol Clin North Am. 2017 Mar;46(1):121-141. doi: 10.1016/j.gtc.2016.09.009.
The esophagus and stomach are host to their own population of bacteria, which differs in health and disease. Helicobacter pylori uniquely colonizes only gastric mucosa, but an increasing number of bacteria is now isolated from the gastric juice and gastric mucosa, including Lactobacillus. The presence of H pylori alters populations of other gastric bacteria with a marked reduction in diversity. Alterations in intragastric acidity may be the cause or the consequence of changes in the microbial populations of the stomach. Esophageal inflammation is associated with an altered microbiota in gastroesophageal reflux disease, Barrett's esophagus, eosinophilic esophagitis, and cancer.
食管和胃中都有各自独特的细菌群落，其在健康和疾病状态下有所不同。幽门螺杆菌仅独特地定殖于胃黏膜，但现在从胃液和胃黏膜中分离出的细菌种类越来越多，包括乳酸杆菌。幽门螺杆菌的存在会改变其他胃内细菌的群落，使其多样性显著降低。胃内酸度的改变可能是胃微生物群落变化的原因或结果。在胃食管反流病、巴雷特食管、嗜酸性粒细胞性食管炎和癌症中，食管炎症与微生物群的改变有关。
