Pállinger Éva, Kiss Gergely Attila, Csaba György
1 Department of Genetics, Cell- and Immunobiology, Semmelweis University , Budapest, Hungary.
Acta Microbiol Immunol Hung. 2016 Dec;63(4):373-385. doi: 10.1556/030.63.2016.016. Epub 2016 Dec 12.
Cells of the immune system synthesize, store, and secrete polypeptide and amino acid type hormones, which also influence their functions, having receptors for different hormones. In the present experiment immunophenotyped immune cells isolated from bone marrow, thymus, and peritoneal fluid of mice were used for demonstrating the adrenocorticotropic hormone (ACTH) and triiodothyronine (T3) hormone production of differentiating immune cells. Both hormones were found in each cell type, and in each maturation state, which means that all cells are participating in the hormonal function of the immune system. The lineage-independent presence of ACTH and T3 in differentiating hematopoietic cells denotes that their expression ubiquitous during lymphocyte development. Higher ACTH and T3 content of B cells shows that these cells are the most hormonally active and suggests that the hormones may have an autocrine regulatory role in B cell development. Developing T cells showed heterogeneous hormone production which was associated with their maturation state. Differences in the hormone contents of immune cells isolated from different organs indicate that their hormone production is defined by their differentiation or maturation state, however, possibly also by the local microenvironment.
免疫系统的细胞合成、储存并分泌多肽和氨基酸类激素，这些激素也会影响其功能，且细胞具有针对不同激素的受体。在本实验中，从小鼠的骨髓、胸腺和腹腔液中分离出经免疫表型分析的免疫细胞，用于证明分化中的免疫细胞产生促肾上腺皮质激素（ACTH）和三碘甲状腺原氨酸（T3）。在每种细胞类型以及每种成熟状态下均发现了这两种激素，这意味着所有细胞都参与了免疫系统的激素功能。在分化中的造血细胞中，ACTH和T3不依赖谱系的存在表明它们在淋巴细胞发育过程中普遍表达。B细胞中较高的ACTH和T3含量表明这些细胞是激素活性最高的细胞，并提示这些激素可能在B细胞发育中具有自分泌调节作用。发育中的T细胞显示出与成熟状态相关的异质性激素产生。从不同器官分离出的免疫细胞中激素含量的差异表明，它们的激素产生由其分化或成熟状态决定，不过也可能受局部微环境的影响。
