Kashcooli Meisam, Salimpour Mohammad Reza, Shirani Ebrahim
Department of Mechanical Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
Department of Mechanical Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
J Therm Biol. 2017 Feb;64:7-18. doi: 10.1016/j.jtherbio.2016.12.007. Epub 2016 Dec 18.
Specifying exact geometry of vessel network and its effect on temperature distribution in living tissues is one of the most complicated problems of the bioheat field. In this paper, the effects of blood vessels on temperature distribution in a skin tissue subjected to various thermal therapy conditions are investigated. Present model consists of counter-current multilevel vessel network embedded in a three-dimensional triple-layered skin structure. Branching angles of vessels are calculated using the physiological principle of minimum work. Length and diameter ratios are specified using length doubling rule and Cube law, respectively. By solving continuity, momentum and energy equations for blood flow and Pennes and modified Pennes bioheat equations for the tissue, temperature distributions in the tissue are measured. Effects of considering modified Pennes bioheat equation are investigated, comprehensively. It is also observed that blood has an impressive role in temperature distribution of the tissue, especially at high temperatures. The effects of different parameters such as boundary conditions, relaxation time, thermal properties of skin, metabolism and pulse heat flux on temperature distribution are investigated. Tremendous effect of boundary condition type at the lower boundary is noted. It seems that neither insulation nor constant temperature at this boundary can completely describe the real physical phenomena. It is expected that real temperature at the lower levels is somewhat between two predicted values. The effect of temperature on the thermal properties of skin tissue is considered. It is shown that considering temperature dependent values for thermal conductivity is important in the temperature distribution estimation of skin tissue; however, the effect of temperature dependent values for specific heat capacity is negligible. It is seen that considering modified Pennes equation in processes with high heat flux during low times is significant.
确定血管网络的确切几何形状及其对活体组织温度分布的影响是生物热场中最复杂的问题之一。本文研究了血管对处于各种热疗条件下的皮肤组织温度分布的影响。当前模型由嵌入三维三层皮肤结构中的逆流多级血管网络组成。血管的分支角度使用最小功的生理原理计算。长度和直径比分别使用长度加倍规则和立方定律指定。通过求解血流的连续性、动量和能量方程以及组织的彭尼斯和修正彭尼斯生物热方程,测量组织中的温度分布。全面研究了考虑修正彭尼斯生物热方程的影响。还观察到血液在组织温度分布中起着重要作用,尤其是在高温下。研究了不同参数如边界条件、松弛时间、皮肤热特性、新陈代谢和脉冲热通量对温度分布的影响。注意到下边界处边界条件类型的巨大影响。似乎该边界处的绝缘或恒温都不能完全描述实际物理现象。预计较低层的实际温度在两个预测值之间。考虑了温度对皮肤组织热特性的影响。结果表明,在皮肤组织温度分布估计中考虑与温度相关的热导率值很重要;然而,与温度相关的比热容值的影响可以忽略不计。可以看出,在短时间内热通量较高的过程中考虑修正彭尼斯方程很重要。