Dept. Exp. Cardiology, Academic Medical Center, Amsterdam, The Netherlands; IHU Liryc, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Université, F-33600 Pessac Bordeaux, France.
Pharmacol Ther. 2017 Aug;176:40-47. doi: 10.1016/j.pharmthera.2017.02.004. Epub 2017 Feb 3.
In this review, the pro- and anti-arrhythmic effects of a diet rich in fish oil fatty acids and of hypercholesterolemia will be discussed in relation to two major mechanisms of arrhythmogenesis (triggered activity and re-entry). Whereas a diet rich in fish oil is pro-arrhythmic in relation to re-entry based arrhythmias (as occur in acute myocardial ischemia) and anti-arrhythmic in relation to triggered activity based arrhythmias (as occur in heart failure), the reverse is true for hypercholesterolemia. Changing the lipid composition of cardiomyocytes likely has powerful pro- or anti-arrhythmic consequences, depending on the mechanism of arrhythmias, and has corresponding therapeutic potential.
在这篇综述中，我们将讨论富含鱼油脂肪酸的饮食和高胆固醇血症对心律失常发生的两种主要机制（触发活动和折返）的抗心律失常作用。富含鱼油的饮食与折返性心律失常（如急性心肌缺血时发生的心律失常）有关，具有致心律失常作用，而与触发活动性心律失常（如心力衰竭时发生的心律失常）有关，具有抗心律失常作用，而高胆固醇血症则相反。改变心肌细胞的脂质组成可能会产生强大的致心律失常或抗心律失常作用，具体取决于心律失常的机制，并具有相应的治疗潜力。
