Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
J Ethnopharmacol. 2017 Mar 6;199:183-193. doi: 10.1016/j.jep.2017.02.007. Epub 2017 Feb 5.
The root extract of Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) is traditionally used in the management of pain and fever. However, little scientific data exists in literature to support its use.
The present study evaluated the anti-nociceptive and antipyretic properties of the hydroethanolic extract of the roots of Albizia zygia in animal models.
The analgesic effects were investigated in chemical (acetic acid-induced abdominal writhing and formalin tests), thermal (tail-immersion test) and mechanical (carrageenan-induced hyperalgesia) pain models. Possible mechanisms of anti-nociception were also assessed with antagonists in the formalin test. The anti-pyretic effect was evaluated using the baker yeast-induced pyrexia model in young rats.
The extract (30-300mg/kg, p.o.) and positive controls, diclofenac (3-30mg/kg, i.p.) and morphine (1-10mg/kg, i.p.), significantly (at least P<0.01) attenuated acetic acid-induced visceral pain, formalin- induced paw pain (both neurogenic and inflammatory), thermal pain as well as carrageenan-induced mechanical hyperalgesia in animals. The anti-nociceptive effect of the extract was reversed (at least P<0.05) by the pre-emptive administration of naloxone and atropine; the administration of theophylline, however, exhibited no significant (P>0.05) inhibition of anti-nociception. The extract (30-300mg/kg, p.o) and paracetamol (15-150mg/kg, p.o.) both reversed yeast-induced pyrexia in rats with ED values of 48.59±2.59 and 26.19±1.33mg/kg respectively.
The findings indicate that the extract possesses significant anti-nociceptive and antipyretic effects which justify its traditional use in the management of pain and fever. Also, anti-nociceptive effect of the extract involves opioidergic and muscarinic cholinergic mechanisms.
合欢（DC。）J.F. Macbr。的根提取物（豆科 - 含羞草科）传统上用于治疗疼痛和发热。然而，文献中几乎没有科学数据支持其使用。
本研究评估了合欢根水乙醇提取物在动物模型中的抗伤害和退热特性。
在化学（醋酸诱导的腹部扭曲和福马林试验）、热（尾巴浸入试验）和机械（角叉菜胶诱导的痛觉过敏）疼痛模型中研究了镇痛作用。在福马林试验中还使用拮抗剂评估了抗伤害感受的可能机制。使用年轻大鼠的面包酵母诱导发热模型评估了退热作用。
提取物（30-300mg/kg，po）和阳性对照物，双氯芬酸（3-30mg/kg，ip）和吗啡（1-10mg/kg，ip），显著（至少 P<0.01）减轻了醋酸引起的内脏疼痛，福马林诱导的爪痛（神经源性和炎症性），热痛以及角叉菜胶诱导的机械性痛觉过敏。预先给予纳洛酮和阿托品可逆转提取物的镇痛作用（至少 P<0.05）；然而，茶碱的给药并未显著（P>0.05）抑制镇痛作用。提取物（30-300mg/kg，po）和对乙酰氨基酚（15-150mg/kg，po）均逆转了大鼠的酵母诱导发热，其 ED 值分别为 48.59±2.59 和 26.19±1.33mg/kg。
这些发现表明，提取物具有显著的镇痛和解热作用，证明了其在疼痛和发热管理中的传统用途。此外，提取物的镇痛作用涉及阿片能和毒蕈碱胆碱能机制。
