Ezzati A O, Studenski M T
University of Tabriz, Faculty of Physics, Tabriz, Iran.
University of Miami, Department of Radiation Oncology, Miami, FL, United States.
Appl Radiat Isot. 2017 Apr;122:186-192. doi: 10.1016/j.apradiso.2017.01.046. Epub 2017 Feb 1.
In radiation therapy, neutron contamination is an undesirable side effect of using high energy photons to treat patients. Neutron contamination requires adjustments to the shielding requirements of the linear accelerator vault and contributes to the risk of secondary malignancies in patients by delivering dose outside of the primary treatment field. Using MCNPX, an established Monte Carlo code, manufacturer blueprints, and the most up to date ICRP neutron dose conversion factors, the neutron spectra, neutron/photon dose ratio, and the neutron capture gamma ray dose were calculated at different depths and off axis distances in a tissue equivalent phantom. Results demonstrated that the neutron spectra and dose are dependent on field size, depth in the phantom, and off-axis distance. Simulations showed that because of the low neutron absorption cross section of the linear accelerator head materials, the contribution to overall patient dose from neutrons can be up to 1000 times the photon dose out of the treatment field and is also dependent on field size and depth. Beyond 45cm off-axis, the dependence of the neutron dose on field size is minimal. Neutron capture gamma ray dose is also field size dependent and is at a maximum at a depth of about 7cm. It is important to remember that when treating with high energy photons, the dose from contamination neutrons must be considered as it is much greater than the photon dose.
在放射治疗中,中子污染是使用高能光子治疗患者时产生的不良副作用。中子污染需要调整直线加速器治疗室的屏蔽要求,并通过在主要治疗区域之外输送剂量,增加患者发生继发性恶性肿瘤的风险。利用成熟的蒙特卡罗代码MCNPX、制造商蓝图以及最新的国际辐射防护委员会(ICRP)中子剂量转换因子,在组织等效体模中的不同深度和离轴距离处计算了中子能谱、中子/光子剂量比以及中子俘获γ射线剂量。结果表明,中子能谱和剂量取决于射野大小、体模深度和离轴距离。模拟显示,由于直线加速器机头材料的中子吸收截面较低,中子对患者总剂量的贡献在治疗区域之外可达光子剂量的1000倍,并且也取决于射野大小和深度。离轴距离超过45cm时,中子剂量对射野大小的依赖性最小。中子俘获γ射线剂量也取决于射野大小,并且在约7cm深度处最大。重要 的是要记住,在使用高能光子进行治疗时,必须考虑污染中子的剂量,因为它远大于光子剂量。