调控染色体不稳定性以优化肿瘤适应性。
Tuning Chromosomal Instability to Optimize Tumor Fitness.
机构信息
Department of Medicine Hematology/Oncology, University of Wisconsin-Madison, Madison, Wisconsin.
UW Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.
出版信息
Cancer Discov. 2017 Feb;7(2):134-136. doi: 10.1158/2159-8290.CD-16-1415.
Abstract
Low rates of chromosomal instability (CIN) are weakly tumor promoting, whereas high rates of CIN cause cell death and tumor suppression. In this context, Sansregret and colleagues show that one mechanism to restrain excessive CIN in tumor cells and increase fitness is through mutations in the anaphase promoting complex/cyclosome. This serves to delay mitotic progression and decrease the rate of chromosome missegregation. Cancer Discov; 7(2); 134-6. ©2017 AACRSee related article by Sansregret et al., p. 218.
摘要
低水平的染色体不稳定性（CIN）具有微弱的促肿瘤作用，而高水平的 CIN 则导致细胞死亡和肿瘤抑制。在这种情况下，Sansregret 及其同事表明，一种限制肿瘤细胞中过度 CIN 并提高适应性的机制是通过在后期促进复合物/周期素中的突变。这有助于延迟有丝分裂进程并降低染色体错误分离的速率。癌症发现；7(2)；134-6。©2017AACR 见 Sansregret 等人的相关文章，第 218 页。
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