Jallepalli P V, Lengauer C
The Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA.
Nat Rev Cancer. 2001 Nov;1(2):109-17. doi: 10.1038/35101065.
Mitosis is the most dramatic--and potentially dangerous--event in the cell cycle, as sister chromatids are irreversibly segregated to daughter cells. Defects in the checkpoints that normally maintain the fidelity of this process can lead to chromosomal instability (CIN) and cancer. However, CIN--a driving force of tumorigenesis--could be the cancer cell's ultimate vulnerability. An important goal is to identify novel anticancer compounds that directly target the mitotic errors at the heart of CIN.
有丝分裂是细胞周期中最剧烈且可能危险的事件，因为姐妹染色单体不可逆地分离到子细胞中。通常维持这一过程保真度的检查点出现缺陷会导致染色体不稳定（CIN）和癌症。然而，CIN作为肿瘤发生的驱动力，可能是癌细胞的最终弱点。一个重要目标是鉴定直接针对CIN核心有丝分裂错误的新型抗癌化合物。
