Zeng Li, Xiao Cai Zhi, Deng Zi Ting, Li Rong Heng
Department of Combination of Chinese and Western Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; Laboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Laboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; Department of Traditional Chinese Medicine for Tumor, Chongqing Cancer Institute, Chongqing 400030, China.
Evid Based Complement Alternat Med. 2017;2017:8985623. doi: 10.1155/2017/8985623. Epub 2017 Jan 11.
Fu Yuan Capsule (FYC) has been clinically used for osteoarthritis (OA) and its related diseases for many years in China. However, its pharmacological mechanism remains unclear. This study aimed to investigate the potential chondroprotective effects of FYC on articular cartilage. Rat OA model was induced by anterior cruciate ligament transection. A group of rats was treated with FYC for 12 weeks. Joint structure, types I and II collagen, and proteoglycan were evaluated by histological examination. The expression of C-terminal crosslinking telopeptide of type II collagen, hydroxyproline, a disintegrin and metalloproteinase with thrombospondin motifs, matrix metalloproteinase, interleukin-1 beta, nitric oxide, prostaglandin E2, heat-shock protein 70, transforming growth factor-beta, osteoprotegerin, and receptor activator of nuclear factor B ligand were detected. Treatment with FYC could protect against articular cartilage injury. FYC treatment significantly decreased the extracellular matrix degradation factors and inflammatory mediators. Moreover, articular cartilage protective factors were increased in the FYC group. The current finding suggests that FYC protects articular cartilage in a rat OA model through various ways. Thus, it may be an effective agent for OA treatment.
复方伤痛胶囊（FYC）在中国已临床用于骨关节炎（OA）及其相关疾病多年。然而，其药理机制仍不清楚。本研究旨在探讨复方伤痛胶囊对关节软骨的潜在软骨保护作用。通过切断前交叉韧带诱导大鼠骨关节炎模型。一组大鼠用复方伤痛胶囊治疗12周。通过组织学检查评估关节结构、I型和II型胶原蛋白以及蛋白聚糖。检测II型胶原蛋白C端交联末端肽、羟脯氨酸、含血小板反应蛋白基序的解聚素和金属蛋白酶、基质金属蛋白酶、白细胞介素-1β、一氧化氮、前列腺素E2、热休克蛋白70、转化生长因子-β、骨保护素和核因子κB受体活化因子配体的表达。复方伤痛胶囊治疗可预防关节软骨损伤。复方伤痛胶囊治疗显著降低细胞外基质降解因子和炎症介质。此外，复方伤痛胶囊组的关节软骨保护因子增加。目前的研究结果表明，复方伤痛胶囊通过多种方式保护大鼠骨关节炎模型中的关节软骨。因此，它可能是一种治疗骨关节炎的有效药物。
