Okamoto Koichi, Amari Masakuni, Fukuda Toshio, Suzuki Keiji, Takatama Masamitsu
Department of Neurology, Geriatrics Research Institute and Hospital, Maebashi, Gunma, Japan.
Department of Pathology, Geriatrics Research Institute and Hospital, Maebashi, Gunma, Japan.
Neuropathology. 2017 Aug;37(4):306-310. doi: 10.1111/neup.12367. Epub 2017 Feb 6.
We compared semiquantitatively AT8 immunoreactivity in the locus ceruleus (LC) and hippocampus of 154 brains from routine autopsies to investigate the initial sites of phosphorylated tau (phospho-tau) development. The numbers of AT8-positive neurons and the severity of AT8-positive neuropil threads (NTs) in the LC were strongly associated: there were no cases with AT8-positive neurons that lacked NTs and 20 cases (13%) had only NTs in the LC. Phospho-tau pathologies in the LC were almost equally on both sides, although some cases (7.8%) showed unilateral predominance. The numbers of AT8-positive neurons in the LC and the numbers of AT8-positive neurons and NTs in the hippocampus were also strongly associated. There were only two cases with AT8-positive neurons in the LC that lacked phospho-tau pathology in the hippocampus, and 21 cases (13.6%) with phospho-tau pathology in the hippocampus that lacked AT8-positive neurons in the LC. The numbers of AT8-positive NTs in the LC and AT8-positive neurons and NTs in the hippocampus were also strongly associated. There were seven cases (4.5%) with AT8-positive NTs in the LC that lacked phospho-tau pathology in the hippocampus, and five cases (3.2 %) with phospho-tau pathologies in the hippocampus that lacked AT8-positive NTs in the LC. In this study, we could not confirm that phospho-tau pathologies begin in the LC. We suspect their simultaneous occurrences in both hippocampal regions and in LC.
我们对154例常规尸检大脑的蓝斑（LC）和海马体中的AT8免疫反应性进行了半定量比较，以研究磷酸化tau蛋白（磷酸化tau）发展的起始部位。LC中AT8阳性神经元的数量与AT8阳性神经原纤维（NTs）的严重程度密切相关：不存在没有NTs的AT8阳性神经元病例，20例（13%）在LC中仅有NTs。尽管有些病例（7.8%）表现为单侧优势，但LC中的磷酸化tau病变在两侧几乎相等。LC中AT8阳性神经元的数量与海马体中AT8阳性神经元和NTs的数量也密切相关。LC中仅有两例AT8阳性神经元的病例在海马体中缺乏磷酸化tau病变情况，21例（13.6%）海马体中有磷酸化tau病变的病例在LC中缺乏AT8阳性神经元。LC中AT8阳性NTs的数量与海马体中AT8阳性神经元和NTs的数量也密切相关。LC中有7例（4.5%）AT8阳性NTs的病例在海马体中缺乏磷酸化tau病变情况，5例（3.2%）海马体中有磷酸化tau病变的病例在LC中缺乏AT8阳性NTs。在本研究中，我们无法证实磷酸化tau病变始于LC。我们怀疑它们在海马体区域和LC中同时出现。
