Cobos E, Gandara D R, Geier L J, Kirmani S
Department of Medicine, Letterman Army Medical Center Presidio, San Francisco.
Am J Hematol. 1989 Nov;32(3):235-6. doi: 10.1002/ajh.2830320316.
Post-transfusion purpura and isoimmune neonatal thrombocytopenia are rare and unusual syndromes leading to severe thrombocytopenia. In both disorders the PLA1 platelet antigen is involved in the pathogenesis. A 41-year-old woman with an obstetrical history of isoimmune neonatal thrombocytopenia in two of her children developed post-transfusion purpura following a transfusion of packed red blood cells. Despite the apparent link in these two disorders associated with the PLA1 platelet antigen, this is the first reported case of post-transfusion purpura and isoimmune neonatal thrombocytopenia occurring in the same family.
输血后紫癜和同种免疫性新生儿血小板减少症是导致严重血小板减少的罕见且特殊的综合征。在这两种疾病中，PLA1血小板抗原均参与发病机制。一名41岁女性，其两名子女有同种免疫性新生儿血小板减少症的产科病史，在输注浓缩红细胞后发生了输血后紫癜。尽管这两种与PLA1血小板抗原相关的疾病之间存在明显联系，但这是首例报道的同一家庭中发生输血后紫癜和同种免疫性新生儿血小板减少症的病例。
