羰基的有机催化氢膦酰化反应

Organocatalytic Hydrophosphonylation Reaction of Carbonyl Groups.

作者信息

Herrera Raquel P

机构信息

Laboratorio de Organocatálisis Asimétrica. Departamento de Química Orgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH) CSIC-, Universidad de Zaragoza, C/ Pedro Cerbuna N°12, 50009, Zaragoza, Spain.

出版信息

Chem Rec. 2017 Sep;17(9):833-840. doi: 10.1002/tcr.201600129. Epub 2017 Feb 7.

DOI:10.1002/tcr.201600129

PMID:28169484

Abstract

This revision is covering the limited examples reported for a pivotal strategy in the formation of C-P bonds such as the asymmetric organocatalytic hydrophosphonylation of carbonyl groups (Pudovik reaction). The scope and limitations, and the proposed mechanisms for the scarce different possibilities of asymmetric induction are also shown. The recent evolution and future trends of this undeveloped approach are commented.

摘要

本次修订涵盖了为形成碳 - 磷键的关键策略所报道的有限示例，例如羰基的不对称有机催化氢膦酰化反应（普多夫尼克反应）。文中还展示了该反应的范围和局限性，以及针对不对称诱导的几种罕见不同可能性所提出的反应机理。此外，还对这种未充分发展的方法的最新进展和未来趋势进行了评论。