Akiyama Takahiko, Morita Hisashi, Itoh Junji, Fuchibe Kohei
Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, Japan.
Org Lett. 2005 Jun 23;7(13):2583-5. doi: 10.1021/ol050695e.
[reaction: see text] A cyclic phosphoric acid derivative, derived from (R)-BINOL, was used as a chiral Brønsted acid (10 mol %) in hydrophosphonylation of aldimines with diisopropyl phosphite at room temperature. Alpha-amino phosphonates were obtained with good to high enantioselectivities.
[反应：见正文] 一种由（R）-联萘酚衍生的环状磷酸衍生物，在室温下用作手性布朗斯特酸（10摩尔%），用于亚胺与亚磷酸二异丙酯的氢膦酰化反应。以良好至高的对映选择性得到了α-氨基膦酸酯。
