Henson K, Files J C, Morrison F S
Department of Medicine, Division of Hematology, University Medical Center, Jackson, Mississippi 39216.
Am J Med. 1989 Nov;87(5):583-5. doi: 10.1016/s0002-9343(89)80618-7.
Acquired deficiency of factor X is an uncommon occurrence. It has usually developed in association with amyloidosis [8] and, in that setting, it has been irreversible. Transient deficiency appears to be associated with an acute respiratory infection in the majority of cases. Bleeding in these patients can be life-threatening and has been difficult to control. Konyne produces a brief correction of the prothrombin time and an elevation in the factor X level, but has not been effective in stopping bleeding. We report the first successful correction of prothrombin time and clinical resolution of bleeding attending the use of Autoplex T. If bleeding persists after appropriate specific factor replacement and the clinical condition warrants, the use of Autoplex T (activated prothrombin complex) deserves prompt consideration.
获得性X因子缺乏症并不常见。它通常与淀粉样变性相关[8]，在这种情况下，它是不可逆的。在大多数病例中，短暂性缺乏似乎与急性呼吸道感染有关。这些患者的出血可能危及生命且难以控制。科尼因能使凝血酶原时间得到短暂纠正，X因子水平升高，但在止血方面无效。我们报告了首例使用自体凝血活酶复合物（Autoplex T）成功纠正凝血酶原时间并使出血临床症状缓解的病例。如果在适当的特异性因子替代治疗后出血仍持续，且临床情况允许，应立即考虑使用自体凝血活酶复合物（活化凝血酶原复合物）。
