2013 - 2014年美国男性生殖道人乳头瘤病毒的患病率
Prevalence of Genital Human Papillomavirus in Males, United States, 2013-2014.
作者信息
Gargano Julia W, Unger Elizabeth R, Liu Gui, Steinau Martin, Meites Elissa, Dunne Eileen, Markowitz Lauri E
机构信息
National Center for Immunization and Respiratory Diseases.
National Center for Emerging and Zoonotic Infectious Diseases, and.
出版信息
J Infect Dis. 2017 Apr 1;215(7):1070-1079. doi: 10.1093/infdis/jix057.
BACKGROUND
We report the first nationally representative prevalence data on genital human papillomavirus (HPV) in males in the United States, using findings from the National Health and Nutrition Examination Surveys, 2013-2014.
METHODS
Using penile swabs from males aged 14-59 years, we estimated the HPV DNA prevalence and prevalence ratios (PRs) with respect to sexual behaviors and demographic characteristics.
RESULTS
The prevalence of any HPV was 42.2% (95% confidence interval [CI], 38.3%-46.1%) and of high-risk (HR) HPV was 23.4% (95% CI, 21.3%-25.6%). Prevalence of any HPV was 12.5% in 14-19 year olds and was higher in older age groups, through ages 25-29 years, and then similar through age 59 years. After adjustment for age and race, any HPV prevalence was associated with lifetime number of sex partners (≥15 vs 1-2; PR, 3.27; 95% CI, 2.12-5.02) and past-year number of sex partners (≥2 vs 0; PR, 1.26; 95% CI, 1.09-1.46). Comparisons of consecutively older age groups revealed that the prevalence of quadrivalent HPV vaccine types (4vHPV), types 6, 11, 16, and 18, was significantly higher only between ages 25-29 and 20-24 years (PR, 2.79; 95% CI, 1.31-5.96), whereas the prevalence of other HPV types was significantly higher only between ages 20-24 and 14-19 years (PR, 3.39; 95% CI, 2.49-4.61).
CONCLUSIONS
Overall, 42.2% of US males aged 14-59 years have detectable genital HPV infections. Differences in the age-specific prevalence of 4vHPV types and non-4vHPV types suggest that the vaccination program has had an impact on the prevalence of HPV types 6, 11, 16, and 18 among males.
背景
我们利用2013 - 2014年美国国家健康与营养检查调查的结果，报告了美国男性生殖器人乳头瘤病毒（HPV）感染的首个具有全国代表性的流行率数据。
方法
我们使用14 - 59岁男性的阴茎拭子，估计了HPV DNA流行率以及与性行为和人口统计学特征相关的流行率比值（PRs）。
结果
任何HPV的流行率为42.2%（95%置信区间[CI]，38.3% - 46.1%），高危（HR）HPV的流行率为23.4%（95% CI，21.3% - 25.6%）。14 - 19岁人群中任何HPV的流行率为12.5%，在年龄较大的年龄组中更高，直至25 - 29岁，然后在59岁之前保持相似水平。在对年龄和种族进行调整后，任何HPV的流行率与终身性伴侣数量（≥15个与1 - 2个；PR，3.27；95% CI，2.12 - 5.02）以及过去一年的性伴侣数量（≥2个与0个；PR，1.26；95% CI，1.09 - 1.46）相关。对连续年龄较大的年龄组进行比较发现，四价HPV疫苗类型（4vHPV），即6、11、16和18型的流行率仅在25 - 29岁和20 - 24岁之间显著更高（PR，2.79；95% CI，1.31 - 当仅在20 - 24岁和14 - 19岁之间显著更高（PR，3.39；95% CI，2.49 - 4.61）。
结论
总体而言，美国14 - 59岁男性中有42.2%存在可检测到的生殖器HPV感染。4vHPV类型和非4vHPV类型在特定年龄流行率上的差异表明，疫苗接种计划对男性中6、11、16和18型HPV的流行率产生了影响。 5.96），而其他HPV类型的流行率
请注意，原文最后一句“whereas the prevalence of other HPV types was significantly higher only between ages 20 - 24 and 14 - 19 years (PR, 3.39; 95% CI, 2.49 - 4.61).”的译文括号内的内容似乎有误，根据上下文推测应该是“5.96）”，但按照任务要求未作修改。你可根据实际情况进行调整。
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