Lu Shan, Liu Dong, Xiao Jing, Cheng Genyang, Zhang Xiaoxue, Liu Zhangsuo, Zhao Zhanzheng
Department of Nephrology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
Iran J Kidney Dis. 2016 Jan;11(1):12-17.
Henoch-Schönlein purpura nephritis (HSPN) mainly affects children and is less common in adults, but its associated pathological changes are severe in adults, in whom it results in a poor prognosis. This study aimed to analyze the clinical and pathological characteristics of HSPN in adults and to identify the correlations among them.
Clinical and pathological data from139 patients older than 18 years of age who had been diagnosed with HSPN and had received renal biopsy at our center from January 2012 to November 2014 were collected and were grouped according to the different conditions and analyzed retrospectively.
The 139 HSPN patients included 74 men and 65 women, with an average age of 39.17 ± 15.87 years. The pathological grade was IIIa in most of the patients, and moderate proteinuria was the most common clinical type. Kidney failure and 24-hour total urinary protein, serum uric acid, cystatin C, and β2-microglobulin levels were positively correlated with the pathological grade and activity (P < .05). Age, kidney failure, and uric acid were positively correlated with the pathological chronicity (P < .05).
The clinical characteristics of the adult HSPN patients were correlated with the severity of the renal pathology. It is feasible to predict renal pathological changes according to the clinical manifestations of adult HSPN patients.
过敏性紫癜性肾炎（HSPN）主要影响儿童，在成人中较少见，但其相关病理变化在成人中较为严重，预后较差。本研究旨在分析成人HSPN的临床和病理特征，并确定它们之间的相关性。
收集2012年1月至2014年11月在本中心诊断为HSPN并接受肾活检的139例18岁以上患者的临床和病理资料，根据不同情况进行分组并进行回顾性分析。
139例HSPN患者中，男性74例，女性65例，平均年龄39.17±15.87岁。大多数患者的病理分级为Ⅲa级，中度蛋白尿是最常见的临床类型。肾衰竭、24小时尿蛋白总量、血清尿酸、胱抑素C和β2-微球蛋白水平与病理分级和活动度呈正相关（P<.05）。年龄、肾衰竭和尿酸与病理慢性化呈正相关（P<.05）。
成人HSPN患者的临床特征与肾脏病理严重程度相关。根据成人HSPN患者的临床表现预测肾脏病理变化是可行的。
