Li Wenfeng, Lan Ping
Collaborative Innovation Center of Sustainable Forestry in Southern China of Jiangsu Province, College of Biology and the Environment, Nanjing Forestry UniversityNanjing, China; State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of SciencesNanjing, China.
State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences Nanjing, China.
Front Plant Sci. 2017 Jan 24;8:40. doi: 10.3389/fpls.2017.00040. eCollection 2017.
Iron (Fe) is an essential plant micronutrient but is toxic in excess. Fe deficiency chlorosis is a major constraint for plant growth and causes severe losses of crop yields and quality. Under Fe deficiency conditions, plants have developed sophisticated mechanisms to keep cellular Fe homeostasis via various physiological, morphological, metabolic, and gene expression changes to facilitate the availability of Fe. Ethylene has been found to be involved in the Fe deficiency responses of plants through pharmacological studies or by the use of ethylene mutants. However, how ethylene is involved in the regulations of Fe starvation responses remains not fully understood. Over the past decade, omics approaches, mainly focusing on the RNA and protein levels, have been used extensively to investigate global gene expression changes under Fe-limiting conditions, and thousands of genes have been found to be regulated by Fe status. Similarly, proteome profiles have uncovered several hallmark processes that help plants adapt to Fe shortage. To find out how ethylene participates in the Fe deficiency response and explore putatively novel regulators for further investigation, this review emphasizes the integration of those genes and proteins, derived from omics approaches, regulated both by Fe deficiency, and ethylene into a systemic network by gene co-expression analysis.
铁（Fe）是植物必需的微量营养素，但过量时具有毒性。缺铁黄化是植物生长的主要限制因素，会导致作物产量和品质严重下降。在缺铁条件下，植物通过各种生理、形态、代谢和基因表达变化，形成了复杂的机制来维持细胞内铁的稳态，以促进铁的有效性。通过药理学研究或使用乙烯突变体，已发现乙烯参与植物的缺铁反应。然而，乙烯如何参与缺铁反应的调控仍未完全了解。在过去十年中，组学方法主要聚焦于RNA和蛋白质水平，已被广泛用于研究缺铁条件下的全局基因表达变化，并且发现数千个基因受铁状态调控。同样，蛋白质组图谱揭示了几个有助于植物适应铁缺乏的标志性过程。为了弄清楚乙烯如何参与缺铁反应，并探索可能的新型调控因子以供进一步研究，本综述强调通过基因共表达分析，将那些来自组学方法、受缺铁和乙烯共同调控的基因和蛋白质整合到一个系统网络中。
