人类白细胞抗原DRB1*03作为精神分裂症、格雷夫斯病和2型糖尿病可能的共同病因。
HLA DRB1*03 as a possible common etiology of schizophrenia, Graves' disease, and type 2 diabetes.
作者信息
Sayeh Aicha, Ben Cheikh Cheker, Mardessi Ali, Mrad Meriem, Nsiri Brahim, Oumaya Abdelaziz, Fekih-Mrissa Najiba
机构信息
Laboratoire de Biologie Moléculaire, Service d'Hématologie., Hôpital Militaire de Tunis, Montfleury, 1008 Tunis, Tunisia.
Faculté des Sciences de Tunis, Université Tunis el Manar, 2092 Tunis, Tunisia.
出版信息
Ann Gen Psychiatry. 2017 Feb 2;16:7. doi: 10.1186/s12991-017-0128-4. eCollection 2017.
BACKGROUND
Autoimmune diseases and schizophrenia share many common features. Association studies confirm a shared genetic association in the human leukocyte antigen (HLA) region between schizophrenia and most autoimmune diseases. To our knowledge, the simultaneous syndromes of Graves' disease (GD) and type 2 diabetes (T2D) in schizophrenia are rare in Tunisia.
CASE PRESENTATION
We report a case of a 42-year-old woman admitted to the department of psychiatry for an acute relapse of chronic schizophrenia. Her medical history revealed that she was followed for Graves' disease and for a type 2 diabetes mellitus. A low-resolution HLA typing was performed by polymerase chain reaction sequence-specific primer (PCR-SSP) techniques according to determine the patient's haplotype.
CONCLUSIONS
Our study suggests that the HLA DRB1*03 allele may explain a common etiology underlying the co-morbidity of Graves' disease, type 2 diabetes, and schizophrenia in our patient.
背景
自身免疫性疾病和精神分裂症有许多共同特征。关联研究证实，精神分裂症与大多数自身免疫性疾病在人类白细胞抗原（HLA）区域存在共同的遗传关联。据我们所知，突尼斯精神分裂症患者同时患有格雷夫斯病（GD）和2型糖尿病（T2D）的综合征很罕见。
病例报告
我们报告一例42岁女性，因慢性精神分裂症急性复发入住精神科。她的病史显示她因格雷夫斯病和2型糖尿病接受治疗。采用聚合酶链反应序列特异性引物（PCR-SSP）技术进行低分辨率HLA分型，以确定患者的单倍型。
结论
我们的研究表明，HLA DRB1*03等位基因可能解释了我们患者中格雷夫斯病、2型糖尿病和精神分裂症共病的共同病因。
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