Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
Biomed Res Int. 2021 May 28;2021:6693909. doi: 10.1155/2021/6693909. eCollection 2021.
After the announcement of a new coronavirus in China in December 2019, which was then called SARS-CoV-2, this virus changed to a global concern and it was then declared as a pandemic by WHO. Human leukocyte antigen (HLA) alleles, which are one of the most polymorphic genes, play a pivotal role in both resistance and vulnerability of the body against viruses and other infections as well as chronic diseases. The association between HLA alleles and preexisting medical conditions such as cardiovascular diseases and diabetes mellitus is reported in various studies. In this review, we focused on the bioinformatic HLA studies to summarize the HLA alleles which responded to SARS-CoV-2 peptides and have been used to design vaccines. We also reviewed HLA alleles that are associated with comorbidities and might be related to the high mortality rate among COVID-19 patients. Since both genes and patients' medical conditions play a key role in both severity of the disease and the mortality rate in COVID-19 patients, a better understanding of the connection between HLA alleles and SARS-CoV-2 can provide a wider perspective on the behavior of the virus. Such understanding can help scientists, especially in terms of protecting healthcare workers and designing effective vaccines.
2019 年 12 月中国宣布一种新型冠状病毒（随后被称为 SARS-CoV-2）后，该病毒成为全球关注的焦点，世界卫生组织随后宣布其为大流行。人类白细胞抗原（HLA）等位基因是最具多态性的基因之一，在人体对病毒和其他感染以及慢性疾病的抵抗力和易感性方面发挥着关键作用。已有研究报道 HLA 等位基因与心血管疾病和糖尿病等既有医疗条件之间存在关联。在这篇综述中，我们专注于 HLA 的生物信息学研究，以总结对 SARS-CoV-2 肽有反应并被用于设计疫苗的 HLA 等位基因。我们还综述了与合并症相关且可能与 COVID-19 患者高死亡率有关的 HLA 等位基因。由于基因和患者的医疗条件都在 COVID-19 患者的疾病严重程度和死亡率中发挥关键作用，因此更好地了解 HLA 等位基因与 SARS-CoV-2 之间的关系可以更全面地了解病毒的行为。这种了解可以帮助科学家，特别是在保护医护人员和设计有效疫苗方面。
