Park H S, Oh S H, Hong C S
Department of Internal Medicine, Yonsei University College of Medicine, Seoul Korea.
Ann Allergy. 1989 Nov;63(5):399-404.
The allergic responses of 52 bronchial asthma patients who exhibited a positive bronchoprovocation test with house dust and 50 allergic rhinitis patients who had positive RAST results to Dermatophagoides farinae (D. farinae) were studied, including the measurement of D. farinae-specific IgE using D. farinae-RAST, total IgE and skin reactivity to D. farinae and house dust. A comparison between the allergic rhinitis group in which methacholine PC20 was more than 4.66 mg/mL and the allergic rhinitis group which presented negative results in the methacholine bronchial challenge test, indicated that there were significant differences in skin test reactivity and the ratio of specific IgE to total IgE (P less than .05). The allergic responses we observed were not different between the allergic rhinitis group in which methacholine PC20 was less than 4.66 mg/mL (asthmatic range of methacholine PC20) and the allergic rhinitis group in which methacholine PC20 was more than 4.66 mg/mL. When comparing the bronchial asthma group which showed positive results in D. farinae-RAST and the allergic rhinitis group in which methacholine PC20 was less than 4.66 mg/mL, significant differences were noted in total IgE level (P less than .05). These findings suggest that the development of bronchial asthma in patients with allergic rhinitis might be predicted by measuring the degree of bronchial hyperreactivity and their allergic responses.
对52名支气管激发试验对屋尘呈阳性的支气管哮喘患者和50名对粉尘螨RAST检测结果呈阳性的变应性鼻炎患者的过敏反应进行了研究，包括使用粉尘螨RAST检测粉尘螨特异性IgE、总IgE以及对粉尘螨和屋尘的皮肤反应性。对乙酰甲胆碱PC20大于4.66mg/mL的变应性鼻炎组和乙酰甲胆碱支气管激发试验呈阴性结果的变应性鼻炎组进行比较，结果表明皮肤试验反应性以及特异性IgE与总IgE的比值存在显著差异（P<0.05）。我们观察到，乙酰甲胆碱PC20小于4.66mg/mL（乙酰甲胆碱PC20的哮喘范围）的变应性鼻炎组和乙酰甲胆碱PC20大于4.66mg/mL的变应性鼻炎组之间的过敏反应没有差异。比较粉尘螨RAST检测呈阳性结果的支气管哮喘组和乙酰甲胆碱PC20小于4.66mg/mL的变应性鼻炎组，发现总IgE水平存在显著差异（P<0.05）。这些发现表明，通过测量支气管高反应性程度及其过敏反应，可能预测变应性鼻炎患者支气管哮喘的发生。
