Bener A, Safa W, Abdulhalik S, Lestringant G G
Department of Community Medicine, Faculty of Medicine & Health Sciences, Tawam Hospital, Ministry of Health, Al-Ain, UAE.
Allerg Immunol (Paris). 2002 Oct;34(8):281-6.
Studies have shown that allergens are very important sensitizing agents in patients with asthma. Respiratory disorders such as asthma and allergic rhinitis are common in the United Arab Emirates, (UAE).
The aim of this study was to investigate the relationship between allergen specific IgE antibodies and skin test reactivity in patients with asthma in hot climate and desert Arabian country.
A hospital-based prospective study conducted.
Tawam Teaching Hospital, Al-Ain, UAE.
327 adult patients recruited with respiratory, dermatologic and ophthalmologic diseases of suspected allergic origin who attended Tawam Teaching Hospital of Faculty of Medicine, Al Ain, UAE, during three years from 1996 to 1998.
Skin Prick Test (SPT) and radioallegosorbent tests (RAST) were performed on 327 patients for common allergens. The blood sample was taken for measuring specific IgE concentration.
There were 327 UAE patients of whom 117 (35.8%) were males and 210 (64.2%) were females. The population sample had a higher prevalence of diagnosed asthma among females (48.1%) than in males (36.7%). Skin prick testing showed that 244 patients (74.6%) had positive results, and 83 patients (25.4%) were found to be skin test negative. 44% had a positive family history of asthma. The twelve most common reactions in the United Arab Emirates were: Mesquite (45.5%), Grass Mix (40.7%). Cottonwood (33.1%), Bermuda Grass (31.3%), Kochi (25.8%), Acacia (25.6%), Alfalfa (22.9%), Chenopodium (19.6%), Date palm (13.8%), Cockroach (14.7%), house dust (11.9) and Dust mite (9.5%). Total IgE level (> 100 kU/l) was strongly associated with history of wheeze (p = 0.019), asthma (p = 0.01) and allergic rhinitis (p < 0.0001), atopy (p < 0.0001) and the presence of specific IgE antibodies to grass pollen (p < 0.0001), mite (p = 0.008) and cockroaches (p = 0.025).
The present study revealed that hypersensitivity to pollens, house dust, dust mite and cockroach was common. The family history, environment, and airborne allergens are identified to be risk factors for asthma and other allergic diseases in Arabian Gulf Countries.
研究表明，变应原是哮喘患者非常重要的致敏剂。哮喘和过敏性鼻炎等呼吸道疾病在阿拉伯联合酋长国（UAE）很常见。
本研究旨在调查炎热气候下的沙漠阿拉伯国家哮喘患者中变应原特异性IgE抗体与皮肤试验反应性之间的关系。
进行一项基于医院的前瞻性研究。
阿联酋艾因市的塔瓦姆教学医院。
1996年至1998年期间，327名成年患者因疑似过敏性起源的呼吸道、皮肤和眼科疾病就诊于阿联酋艾因市医学院的塔瓦姆教学医院。
对327名患者进行常见变应原的皮肤点刺试验（SPT）和放射变应原吸附试验（RAST）。采集血样以测量特异性IgE浓度。
327名阿联酋患者中，男性117名（35.8%），女性210名（64.2%）。该人群样本中女性哮喘诊断患病率（48.1%）高于男性（36.7%）。皮肤点刺试验显示，244名患者（74.6%）结果为阳性，83名患者（25.4%）皮肤试验为阴性。44%有哮喘家族史阳性。阿联酋最常见的12种反应为：牧豆树（45.5%）、混合草（40.7%）、三角叶杨（33.1%）、百慕大草（31.3%）、高氏曲霉（25.8%）、阿拉伯金合欢（25.6%）、紫花苜蓿（22.9%）、藜（19.6%）、枣椰树（13.8%）、蟑螂（14.7%）、屋尘（含螨）（11.9%）和尘螨（9.5%）。总IgE水平（>100 kU/l）与喘息病史（p = 0.019）、哮喘（p = 0.01）、过敏性鼻炎（p < 0.0001）、特应性（p < 0.0001）以及对草花粉（p < 0.0001）、螨（p = 0.008）和蟑螂（p = 0.025）的特异性IgE抗体的存在密切相关。
本研究表明，对花粉、屋尘、尘螨和蟑螂过敏很常见。家族史、环境和空气传播的变应原被确定为阿拉伯海湾国家哮喘和其他过敏性疾病的危险因素。
