血清甲状腺球蛋白——其测定及临床应用。

Serum thyroglobulin--its measurement and clinical use.

作者信息

Wilson R, McKillop J H, Jenkins C, Beastall G H, Thomson J A

机构信息

University Department of Medicine, Glasgow Royal Infirmary.

出版信息

Ann Clin Biochem. 1989 Sep;26 ( Pt 5):401-6. doi: 10.1177/000456328902600504.

DOI:10.1177/000456328902600504

PMID:2817751

Abstract

Radioimmunoassays (RIA) have been shown to be unreliable in measuring serum thyroglobulin levels in patients with antithyroglobulin antibodies. The aim of this study was twofold. Firstly to compare the abilities of two immunoradiometric assays (IRMA), one commercially available, the other an 'in house' assay, with a conventional RIA. In addition the prognostic value of serum thyroglobulin levels in patients likely to relapse following a course of antithyroid drugs for Graves' disease was examined. The results obtained showed both of the IRMA methods to be unaffected by the presence of antithyroglobulin antibodies. Serum thyroglobulin levels were found to be poor predictors of relapse or remission following a 12 month course of antithyroid drugs.

摘要

放射免疫分析法（RIA）已被证明在测量抗甲状腺球蛋白抗体患者的血清甲状腺球蛋白水平时不可靠。本研究的目的有两个。首先，比较两种免疫放射分析法（IRMA）的能力，一种是市售的，另一种是“内部”分析法，与传统的RIA进行比较。此外，还研究了接受抗甲状腺药物治疗的Graves病患者血清甲状腺球蛋白水平的预后价值。所得结果表明，两种IRMA方法均不受抗甲状腺球蛋白抗体的影响。结果发现，在接受12个月抗甲状腺药物治疗后，血清甲状腺球蛋白水平对复发或缓解的预测能力较差。