铜（II）诱导胸腺嘧啶的放射增敏作用。
Copper (II) induced radiosensitization of thymine.
作者信息
Bhattacharyya S N, Mandal P C, Chakraborty S
机构信息
Nuclear Chemistry Division, Saha Institute of Nuclear Physics, Bidhannagar Calcutta, India.
出版信息
Anticancer Res. 1989 Jul-Aug;9(4):1181-4.
An aqueous solution of thymine (2 x 10(-3) M, pH 5.6) was irradiated with 60Co gamma-rays in the absence and in the presence of CuSO4 (5 x 10(-4) M) under different conditions. In argon and N2O saturated solutions, the presence of CuSO4 increased the radiosensitivity of thymine to a greater extent, while the product distribution was changed. Thus in the presence of CuSO4 the formation of dimeric products was prevented and the yields of cis-thymine glycol and 5-hydroxymethyl uracil were greatly increased. The sensitized degradation was suggested to be due to the oxidation of the transient hydroxyl adducts of thymine by copper ions.
在不同条件下，对胸腺嘧啶的水溶液（2×10⁻³ M，pH 5.6）在不存在和存在硫酸铜（5×10⁻⁴ M）的情况下用⁶⁰Co γ射线进行辐照。在氩气和N₂O饱和溶液中，硫酸铜的存在在更大程度上提高了胸腺嘧啶的放射敏感性，同时产物分布发生了变化。因此，在硫酸铜存在的情况下，二聚体产物的形成受到抑制，顺式胸腺嘧啶二醇和5-羟甲基尿嘧啶的产率大大提高。敏化降解被认为是由于铜离子对胸腺嘧啶瞬态羟基加合物的氧化作用。
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