N-（膦酰乙酰基）-L-天冬氨酸对人髓系白血病来源细胞系的生长抑制作用及双嘧达莫的调节作用
Growth inhibitory effect of N-(phosphonacetyl)-L-aspartic acid on human myeloid leukemia-derived cell lines and modulation by dipyridamole.
作者信息
Taguchi H, Kubonishi I, Miyoshi I
机构信息
Department of Internal Medicine, Kochi Medical School, Japan.
出版信息
Anticancer Res. 1989 Jul-Aug;9(4):845-8.
Dipyridamole (DIP) inhibited the uptake of tritiated thymidine (TdR), deoxyuridine (UdR) and uridine (UR) in myeloid leukemia-derived cell lines, PL-21 and KCL-22. DIP also inhibited the growth of PL-21 (50% inhibitory concentrations, IC50, 15 microM) and KCL-22 (IC50, 3.0 microM). PALA inhibited the growth of PL-21 (IC50, 68 microM) and KCL-22 (IC50, 62 microM). The growth inhibition by PALA was significantly enhanced by the addition of 1 microM (PL-21) and 0.1 microM (KCL-22) of DIP. The inhibitory effect of PALA or PALA with DIP was completely abolished by the addition of 50 microM of UR in both cell cultures. Clinical evaluation of PALA in combination with DIP is warranted for the treatment of myeloid leukemia.
双嘧达莫（DIP）抑制髓系白血病来源的细胞系PL - 21和KCL - 22对氚标记胸腺嘧啶核苷（TdR）、脱氧尿苷（UdR）和尿苷（UR）的摄取。DIP还抑制PL - 21（50%抑制浓度，IC50，15微摩尔）和KCL - 22（IC50，3.0微摩尔）的生长。N-磷酸乙酰-L-天冬氨酸（PALA）抑制PL - 21（IC50，68微摩尔）和KCL - 22（IC50，62微摩尔）的生长。加入1微摩尔（PL - 21）和0.1微摩尔（KCL - 22）的DIP可显著增强PALA的生长抑制作用。在两种细胞培养物中加入50微摩尔的UR可完全消除PALA或PALA与DIP的抑制作用。PALA联合DIP治疗髓系白血病的临床评估是必要的。
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